Nature Search

Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

How the immune system responds to epithelial cancers beyond neoantigen-driven adaptive immunity is poorly understood. Kansler et al. reveal an innate immune surveillance response mediated by cytotoxic ILC1 sensing of cancer cell-expressed IL-15.

Emily R. Kansler
Saïda Dadi
Ming O. Li
Research26 May 2022
Nature Immunology

Volume: 23, P: 904-915
Author Correction: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

Emily R. Kansler
Saïda Dadi
Ming O. Li
Amendments and Corrections15 Jun 2022
Nature Immunology

Volume: 23, P: 1285
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

Reiko Shinkura
Kazuhiro Kitada
Tasuku Honjo
Research01 May 1999
Nature Genetics

Volume: 22, P: 74-77
Role of cytosolic phospholipase A₂ in allergic response and parturition

Naonori Uozumi
Kazuhiko Kume
Takao Shimizu
Research01 Dec 1997
Nature

Volume: 390, P: 618-622
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

Sidonia Fagarasan
Kazuo Kinoshita
Tasuku Honjo
Research11 Oct 2001
Nature

Volume: 413, P: 639-643
High-throughput identification and quantification of single bacterial cells in the microbiota

Here, Jin et al., develop a method called Barcoding Bacteria for Identification and Quantification (BarBIQ), which allows to both characterize the global microbiome and to identify and quantify single-cell bacterial members in a high-throughput manner.

Jianshi Jin
Reiko Yamamoto
Katsuyuki Shiroguchi
ResearchOpen Access22 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs

Fibroblastic reticular cells influence the function of lymphocytes in secondary lymphoid organs. Ludewig and colleagues demonstrate that they also specifically restrain the activation of group 1 innate lymphoid cells in the presence of microbial stimulation to prevent immunopathology.

Cristina Gil-Cruz
Christian Perez-Shibayama
Burkhard Ludewig
Research31 Oct 2016
Nature Immunology

Volume: 17, P: 1388-1396
Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

Hair follicle–derived cytokines control the tropism and retention of memory T cells in the skin and promote lymphoma.

Takeya Adachi
Tetsuro Kobayashi
Keisuke Nagao
Research19 Oct 2015
Nature Medicine

Volume: 21, P: 1272-1279
Structural basis for amino acid export by DMT superfamily transporter YddG

The X-ray structure of the drug/metabolite transporter (DMT) protein YddG from Starkeya novella reveals a new membrane transport topology, with ten transmembrane segments in an outward-facing state and two pseudo-symmetric inverted structural repeats.

Hirotoshi Tsuchiya
Shintaro Doki
Osamu Nureki
Research30 May 2016
Nature

Volume: 534, P: 417-420
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Dennis Das Gupta
Christoph Paul
Michael Lohoff
ResearchOpen Access22 Apr 2022
Cell Death & Differentiation

Volume: 29, P: 2163-2176
Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

Kawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applied to attenuate a severe inflammation caused by another pathogen.

Masataka Kawakita
Taiki Oyama
Kazuhiko Takahara
ResearchOpen Access16 Mar 2021
Communications Biology

Volume: 4, P: 1-9
Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice

Hitoshi Inokawa
Yasuhiro Umemura
Kazuhiro Yagita
ResearchOpen Access13 Feb 2020
Scientific Reports

Volume: 10, P: 1-13
High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells

Satoshi Nakamizo
Tetsuya Honda
Kenji Kabashima
ResearchOpen Access26 Oct 2017
Scientific Reports

Volume: 7, P: 1-13
Hematopoietic developmental pathways: on cellular basis

H Iwasaki
K Akashi
Reviews15 Oct 2007
Oncogene

Volume: 26, P: 6687-6696

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Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

Author Correction: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

Role of cytosolic phospholipase A₂ in allergic response and parturition

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

High-throughput identification and quantification of single bacterial cells in the microbiota

Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs

Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

Structural basis for amino acid export by DMT superfamily transporter YddG

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice

High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells

Hematopoietic developmental pathways: on cellular basis

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