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Showing 1–11 of 11 results
Advanced filters: Author: Koleka P Mlisana Clear advanced filters
  • South Africa experienced a resurgence in COVID-19 in 2022 driven by Omicron subvariants BA.4 and BA.5. Here, the authors investigate the severity of infections caused by these subvariants, and find no difference in the risk of severe outcomes when compared to Omicron BA.1, whilst all Omicron subvariants were less severe than Delta.

    • Nicole Wolter
    • Waasila Jassat
    • Cheryl Cohen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8
  • The SARS-CoV-2 PANGO lineage C.1.2 has been under monitoring by global health authorities as it has spread worldwide. Here, Bhiman and colleagues characterise the emergence of the lineage, and its neutralisation sensitivity using data from vaccinees and previously infected individuals.

    • Cathrine Scheepers
    • Josie Everatt
    • Jinal N. Bhiman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9
  • The 501Y.V2 variant of SARS-CoV-2 in South Africa became dominant over other variants within weeks of its emergence, suggesting that this variant is linked to increased transmissibility or immune escape.

    • Houriiyah Tegally
    • Eduan Wilkinson
    • Tulio de Oliveira
    Research
    Nature
    Volume: 592, P: 438-443
  • Alexander Pym, Ashlee Earl and colleagues use the whole-genome sequences from 498 strains of Mycobacterium tuberculosis to identify new genotypes conferring resistance to antitubercular drugs. They find that loss-of-function mutations in ald (Rv2780), encoding L-alanine dehydrogenase, are associated with unexplained drug resistance and demonstrate that these mutations confer resistance to D-cycloserine.

    • Christopher A Desjardins
    • Keira A Cohen
    • Alexander S Pym
    Research
    Nature Genetics
    Volume: 48, P: 544-551
  • In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and middle income countries.

    • Anderson F. Brito
    • Elizaveta Semenova
    • Nuno R. Faria
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • Interrogation of 1,365 near whole-genome sequences of SARS-CoV-2 variants isolated in South Africa during the first 6 months of the global pandemic reveals three major monophyletic lineages responsible for more than half of the infections in the country and underscores the value of integrating genomic surveillance methods to inform the national pandemic response.

    • Houriiyah Tegally
    • Eduan Wilkinson
    • Tulio de Oliveira
    Research
    Nature Medicine
    Volume: 27, P: 440-446
  • Plasma from individuals vaccinated with BNT162b2 exhibits 22-fold less neutralization capacity against Omicron (B.1.1.529) than against an ancestral SARS-CoV-2 strain but residual neutralization is maintained in those with high levels of neutralization of ancestral virus.

    • Sandile Cele
    • Laurelle Jackson
    • Alex Sigal
    ResearchOpen Access
    Nature
    Volume: 602, P: 654-656
  • Cross-neutralization assays of early variants and the 501Y.V2 variant of SARS-CoV-2 show that plasma from individuals infected with 501Y.V2 effectively neutralizes all variants, indicating that a vaccine that targets 501Y.V2 may also be effective against other SARS-CoV-2 variants.

    • Sandile Cele
    • Inbal Gazy
    • Alex Sigal
    Research
    Nature
    Volume: 593, P: 142-146
  • Genomic characterization of the SARS-CoV-2 Omicron lineages BA.4 and BA.5, responsible for the fifth COVID-19 pandemic wave in South Africa, shows continued viral diversification and provides insights into the potential mechanisms underlying the ability of the new lineages to outcompete their predecessors.

    • Houriiyah Tegally
    • Monika Moir
    • Tulio de Oliveira
    ResearchOpen Access
    Nature Medicine
    Volume: 28, P: 1785-1790