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Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis

Lipoprotein uptake dependent on sulfated glycosaminoglycans linked to cell-surface proteoglycans is a key determinant of ferroptosis sensitivity in cancer.

Dylan Calhoon
Lingjie Sang
Javier Garcia-Bermudez
Research11 Jun 2025
Nature

Volume: 644, P: 799-808
Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

Javier Garcia-Bermudez
Lou Baudrier
Kıvanç Birsoy
Amendments and Corrections08 Aug 2018
Nature Cell Biology

Volume: 20, P: 1228
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

Genetic screens reveal a compendium of metabolic modifiers of lipid peroxidation. Tetrahydrobiopterin is essential under GPX4 inhibition, acting as a radical-trapping antioxidant that inhibits lipid peroxidation and is regenerated by DHFR.

Mariluz Soula
Ross A. Weber
Kıvanç Birsoy
Research10 Aug 2020
Nature Chemical Biology

Volume: 16, P: 1351-1360
Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

In this work, using a combination of metabolomics and CRISPR-based genetic screens, Garcia-Bermudez, Badgley, Prasad et al. show that pancreatic cancer cells overcome aspartate limitation in hypoxia by upregulating macropinocytosis.

Javier Garcia-Bermudez
Michael A. Badgley
Kıvanç Birsoy
Research20 Jun 2022
Nature Metabolism

Volume: 4, P: 724-738
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA

Using whole-exome sequencing data, Gorelick et al. identify lineage-specific somatic mutations in mitochondrial DNA that affect cancer progression and patient prognosis.

Alexander N. Gorelick
Minsoo Kim
Ed Reznik
Research08 Apr 2021
Nature Metabolism

Volume: 3, P: 558-570
Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism

Bayraktar et al. construct a metabolic coessentiality network to cluster metabolic genes into networks from perturbation datasets derived from 558 cancer cell lines. They identify C12orf49 as an essential component of SREBP processing and cholesterol sensing in mammalian cells.

Erol C. Bayraktar
Konnor La
Kıvanç Birsoy
Research01 Jun 2020
Nature Metabolism

Volume: 2, P: 487-498
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

The authors find that loss of squalene monooxygenase expression alters the lipid metabolism of cancer cells, which confers protection from ferroptotic cell death and thus promotes tumour growth.

Javier Garcia-Bermudez
Lou Baudrier
Kıvanç Birsoy
Research13 Feb 2019
Nature

Volume: 567, P: 118-122
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

Garcia-Bermudez et al. and Sullivan et al. show that endogenous aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours, and that metformin depletes aspartate to limit tumour growth.

Javier Garcia-Bermudez
Lou Baudrier
Kıvanç Birsoy
Research25 Jun 2018
Nature Cell Biology

Volume: 20, P: 775-781

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