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Showing 1–2 of 2 results
Advanced filters: Author: Konstantin Neukirch Clear advanced filters

  • Fatty acid unsaturation by stearoyl-CoA desaturase 1 (SCD1) protects against cellular stress through unclear mechanisms. Here the authors show 1,2-dioleoyl-sn-glycero-3-phospho-(1’-myo-inositol) is an SCD1-derived signaling lipid that regulates stress-adaption, protects against cell death and promotes proliferation.

    • Maria Thürmer
    • André Gollowitzer
    • Andreas Koeberle
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Vitamin E metabolites are proposed to have signalling capacity, but how they may regulate immune responses is still unclear. Here the authors show that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synthesis of lipid mediators of immune activation and inflammatory responses.

    • Helmut Pein
    • Alexia Ville
    • Andreas Koeberle
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17