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Showing 1–8 of 8 results
Advanced filters: Author: Kozhinjampara R Mahendran Clear advanced filters

  • Mirror image peptides are of interest for a range of biotechnology applications. Here, the authors report on the creation of fully functional mirror-image transmembrane pores made of D-amino acid peptides, which have potential in nanopore sensing technologies and cancer therapies.

    • Neilah Firzan CA
    • Kalyanashis Jana
    • Kozhinjampara R. Mahendran
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Crystallographic, biophysical and in silico analyses indicate that the conformational state of the mechanosensitive channel MscS is determined by the reorganization, due to changes in membrane tension, of the lipids within and around the protein.

    • Christos Pliotas
    • A Caroline E Dahl
    • James H Naismith
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 991-998

  • The assembly of transmembrane barrels formed from short synthetic peptides has not been previously demonstrated. Now, a transmembrane pore has been fabricated via the self-assembly of peptides. The 35-amino-acid α-helical peptides are based on the C-terminal D4 domain of the Escherichia coli polysaccharide transporter Wza.

    • Kozhinjampara R. Mahendran
    • Ai Niitsu
    • Hagan Bayley
    Research
    Nature Chemistry
    Volume: 9, P: 411-419

  • Alpha-helix nanopores have a range of potential applications and the inclusion of non-natural amino acids allows for modification. Here, the authors report on the creation of alpha-helix pores using D-amino acids and show the pores formed, have different properties to the L-counterparts and were resistant to proteases.

    • Smrithi Krishnan R
    • Kalyanashis Jana
    • Kozhinjampara R. Mahendran
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The de novo design of functional membrane proteins is a formidable challenge. Now, water-soluble peptides have been designed that assemble into α-helical barrels with accessible, polar and hydrated central channels. Insights from these structures have been used to produce stable membrane-spanning, cation-selective channels.

    • Alistair J. Scott
    • Ai Niitsu
    • Derek N. Woolfson
    Research
    Nature Chemistry
    Volume: 13, P: 643-650