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NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

Dysregulated inflammasome activation is associated with auto-inflammatory diseases. Chadee and colleagues show that prostaglandin E₂ triggers rapid inhibition of the inflammasome component NLRP3 by the kinase PKA. Patients with the inflammatory disease CAPS who have mutations in NLPR3 escape this negative regulation.

Leanne Mortimer
France Moreau
Kris Chadee
Research22 Aug 2016
Nature Immunology

Volume: 17, P: 1176-1186
Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling

Here Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inflammatory bowel disease.

Manish Kumar
Aralia Leon Coria
Kris Chadee
ResearchOpen Access24 Jan 2020
Nature Communications

Volume: 11, P: 1-15
PPARγ is an E3 ligase that induces the degradation of NFκB/p65

NFκB/p65 and PPARγ are both transcription factors that perform distinct but overlapping roles in cellular regulation. Hou et al. report that PPARγ acts as an E3 ubiquitin ligase and promotes Lys48-linked ubiquitination and degradation of p65, terminating NFκB-mediated inflammation and tumorigenesis.

Yongzhong Hou
France Moreau
Kris Chadee
Research18 Dec 2012
Nature Communications

Volume: 3, P: 1-11
VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.

Steve Cornick
Manish Kumar
Kris Chadee
ResearchOpen Access20 Sept 2019
Nature Communications

Volume: 10, P: 1-14
Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis

Sharmin Begum
France Moreau
Kris Chadee
Research07 May 2021
Mucosal Immunology

Volume: 14, P: 1038-1054
Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D

Jeanie Quach
France Moreau
Kris Chadee
Research25 Oct 2018
Mucosal Immunology

Volume: 12, P: 323-339
Entamoeba histolytica stimulates the alarmin molecule HMGB1 from macrophages to amplify innate host defenses

Sharmin Begum
France Moreau
Kris Chadee
Research26 Nov 2019
Mucosal Immunology

Volume: 13, P: 344-356

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NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling

PPARγ is an E3 ligase that induces the degradation of NFκB/p65

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis

Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D

Entamoeba histolytica stimulates the alarmin molecule HMGB1 from macrophages to amplify innate host defenses

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NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling

PPARγ is an E3 ligase that induces the degradation of NFκB/p65

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis

Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D

Entamoeba histolytica stimulates the alarmin molecule HMGB1 from macrophages to amplify innate host defenses

Search

Quick links