The phosphoribosyl pyrophosphate synthase PRPS2 catalyses the first step ofde novo purine nucleotide biosynthesis, and has recently been shown to couple protein and nucleotide metabolism. Zhang et al. demonstrate that PRPS2 activity is regulated by tRNA-dependent post-translational addition of arginine.
- Fangliang Zhang
- Devang M. Patel
- Anna Kashina
