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A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

Entry into the cilium is restricted by a network of proteins at its base. Verhey and colleagues now show that nucleoporins, which localize to the nuclear envelope and regulate nuclear–cytoplasmic traffic, are also present at the cilium base, where they form a size-dependent exclusion barrier.

Hooi Lynn Kee
John F. Dishinger
Kristen J. Verhey
Research04 Mar 2012
Nature Cell Biology

Volume: 14, P: 431-437
Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

Loss of olfactory function is one of the many symptoms of the ciliopathy Bardet–Biedl syndrome. Williams et al. show that Bardet–Biedl proteins are components of intraflagellar transport particles within cilia, and directly visualize their trafficking in native mammalian olfactory neurons.

Corey L. Williams
Jeremy C. McIntyre
Jeffrey R. Martens
ResearchOpen Access15 Dec 2014
Nature Communications

Volume: 5, P: 1-13
Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site

How non-enveloped viruses cross host membranes is incompletely understood. Here, Ravindranet al. show that polyomavirus SV40 recruits kinesin-1 to construct a penetration site on the ER membrane.

Madhu Sudhan Ravindran
Martin F. Engelke
Billy Tsai
ResearchOpen Access24 May 2017
Nature Communications

Volume: 8, P: 1-14
Traffic control: regulation of kinesin motors

How kinesin motors are regulated in cells to ensure the temporal and spatial fidelity of their microtubule-based activities is poorly understood. Recent work has revealed molecular mechanisms that control kinesin autoinhibition, activation, binding to cargos and microtubule tracks, and localization.

Kristen J. Verhey
Jennetta W. Hammond
Reviews01 Nov 2009
Nature Reviews Molecular Cell Biology

Volume: 10, P: 765-777
Engineered kinesin motor proteins amenable to small-molecule inhibition

The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable molecules.

Martin F. Engelke
Michael Winding
Kristen J. Verhey
ResearchOpen Access05 Apr 2016
Nature Communications

Volume: 7, P: 1-12
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

How factors are targeted to cilia remains largely unknown. A ciliary localization signal targets the KIF17 motor, important for intraflagellar transport, to cilia through importin-β2 and RanGTP.

John F. Dishinger
Hooi Lynn Kee
Kristen J. Verhey
Research06 Jun 2010
Nature Cell Biology

Volume: 12, P: 703-710
Axonemal Lumen Dominates Cytosolic Protein Diffusion inside the Primary Cilium

Wangxi Luo
Andrew Ruba
Weidong Yang
ResearchOpen Access17 Nov 2017
Scientific Reports

Volume: 7, P: 1-11

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A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site

Traffic control: regulation of kinesin motors

Engineered kinesin motor proteins amenable to small-molecule inhibition

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

Axonemal Lumen Dominates Cytosolic Protein Diffusion inside the Primary Cilium

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