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Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism

Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.

Yong Fan
Liwei Lyu
Oluf Pedersen
ResearchOpen Access31 Jul 2025
Nature Microbiology

Volume: 10, P: 1918-1939
Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels

Kainate receptors (KARs) contribute to excitatory neurotransmission, neuronal plasticity and neurological disorders. Here, Gangwar et al. present KAR structures in complex with channel blockers NpTx8, PhTx74, KukoA, and spermine, which become trapped inside the channel upon its closure.

Shanti Pal Gangwar
Maria V. Yelshanskaya
Alexander I. Sobolevsky
ResearchOpen Access26 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

Molecular details of how antidepressant drugs bind to the human serotonin transporter are not currently clear. Here, the authors introduce photo-cross-linkers into the protein and map the binding site of several antidepressants.

Hafsteinn Rannversson
Jacob Andersen
Kristian Strømgaard
ResearchOpen Access19 Apr 2016
Nature Communications

Volume: 7, P: 1-9
GLP-1-directed NMDA receptor antagonism for obesity treatment

Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.

Jonas Petersen
Mette Q. Ludwig
Christoffer Clemmensen
ResearchOpen Access15 May 2024
Nature

Volume: 629, P: 1133-1141
Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

PDZ domains facilitate numerous protein-binding interactions, and their prevalence in the human genome has led to their investigation as drug targets. Here, the authors generate semisynthetic PDZ domains containing backbone mutations for the identification of important ligand-binding interactions.

Søren W. Pedersen
Stine B. Pedersen
Kristian Strømgaard
Research29 Jan 2014
Nature Communications

Volume: 5, P: 1-11
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

Super-binding peptides based on sequences of glycine receptors that interact with the neuronal scaffold protein gephyrin are useful for isolating and localizing native gephyrin and for modulation of glycinergic synaptic transmission.

Hans Michael Maric
Torben Johann Hausrat
Kristian Strømgaard
Research28 Nov 2016
Nature Chemical Biology

Volume: 13, P: 153-160
Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

G proteins are the key mediators of G protein-coupled receptor signalling, facilitating a number of important physiological processes. Now, the total synthesis and structure–activity relationship studies have been reported for the only known selective G_q protein inhibitors, the natural cyclic depsipeptides YM-254890 and FR900359.

Xiao-Feng Xiong
Hang Zhang
Kristian Strømgaard
Research25 Jul 2016
Nature Chemistry

Volume: 8, P: 1035-1041
Molecular basis of the alternative recruitment of GABA_A versus glycine receptors through gephyrin

Gephyrin is an adaptor molecule that binds to both GABA_A receptors and glycine receptors. Here Maric et al. present the structure between gephyrin and a peptide from GABA_Areceptor and identify key residues dictating the preference of gephyrin for glycine receptor.

Hans Michael Maric
Vikram Babu Kasaragod
Hermann Schindelin
Research22 Dec 2014
Nature Communications

Volume: 5, P: 1-11
Nanobodies raised against the cytotoxic α-synuclein oligomer are oligomer-specific and promote its cellular uptake

Janni Nielsen
Jannik N. Pedersen
Daniel E. Otzen
ResearchOpen Access02 Jun 2025
npj Biosensing

Volume: 2, P: 1-15
Targeting receptor complexes: a new dimension in drug discovery

Targeting protein complexes, including those containing G protein-coupled receptors or ligand-gated ion channels, could provide opportunities to increase the target and functional selectivity of novel drugs compared with existing therapies, which only target the receptors. This Review discusses the landscape of ligand-gated ion channel and G protein-coupled receptor complexes as therapeutic targets, as well as strategies for their pharmacological modulation.

Mette Ishøy Rosenbaum
Louise S. Clemmensen
Kristian Strømgaard
Reviews11 Nov 2020
Nature Reviews Drug Discovery

Volume: 19, P: 884-901
Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers

Janni Nielsen
Johanne Lauritsen
Daniel E. Otzen
ResearchOpen Access29 Jul 2024
npj Parkinson's Disease

Volume: 10, P: 1-26
Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

Jacob Andersen
Kristoffer B. Ringsted
Anders S. Kristensen
ResearchOpen Access27 Oct 2015
Scientific Reports

Volume: 5, P: 1-12

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