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Showing 1–8 of 8 results
Advanced filters: Author: Kristine Schauer Clear advanced filters

  • The function and position of organelles are pivotal for tumor cell dissemination. Here the authors use melanoma patient samples and animal models to show that peripheral localization of lysosomes promotes metastasis by favoring lysosome exocytosis and cell invasion.

    • Katerina Jerabkova-Roda
    • Marina Peralta
    • Jacky G. Goetz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • By micropatterning cells in polarized shapes the global distribution of endomembranes can be compared and subtle but statistically significant changes can be detected from only tens of cells.

    • Kristine Schauer
    • Tarn Duong
    • Bruno Goud
    Research
    Nature Methods
    Volume: 7, P: 560-566

  • Cells sense mechanical properties of their environment using various cellular structures including focal adhesions. Here, the authors identify flat clathrin-coated structures (CCSs) as mechanosensitive signaling platforms that form independently of contractility and in response to substrate rigidity.

    • Francesco Baschieri
    • Stéphane Dayot
    • Guillaume Montagnac
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Exosome biogenesis is poorly understood. The small GTPases Rab27a and Rab27b and their effectors, Slp4 and Slac2b, control exosome secretion at different steps by regulating the peripheral localization, retention and docking of exosomal precursors, the multivesicular endosomes.

    • Matias Ostrowski
    • Nuno B. Carmo
    • Clotilde Thery
    Research
    Nature Cell Biology
    Volume: 12, P: 19-30

  • Ivaska and colleagues report that endocytosed integrins are able to signal from endosomes in an FAK-dependent manner. They further show that endosomal integrin signalling can promote anoikis resistance and lung colonization in cancer cells.

    • Jonna Alanko
    • Anja Mai
    • Johanna Ivaska
    Research
    Nature Cell Biology
    Volume: 17, P: 1412-1421