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Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy

McGeachan et al. observe oligomeric tau in synapses from individuals with progressive supranuclear palsy and provide evidence that tau pathology may spread through the brain via synapses.

Robert I. McGeachan
Lois Keavey
Tara L. Spires-Jones
ResearchOpen Access16 Jul 2025
Nature Neuroscience

Volume: 28, P: 1622-1634
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological Aβ has differing effects on synapses in live human brain slice cultures.

Robert I. McGeachan
Soraya Meftah
Claire S. Durrant
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-22
Problems with visual statistical learning in developmental dyslexia

Heida Maria Sigurdardottir
Hilda Bjork Danielsdottir
Árni Kristjánsson
ResearchOpen Access04 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Hydrothermal fluid flow triggered by an earthquake in Iceland

Migration of hydrothermal fluids and microseismicity in the Krýsuvík geothermal area, Iceland, was controlled by the development of fractures and permeability following a moderate sized earthquake, according to data from two passive seismic surveys

Laurent Geoffroy
Catherine Dorbath
Aurore Franco
ResearchOpen Access10 Mar 2022
Communications Earth & Environment

Volume: 3, P: 1-9
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Rachel L O’Connell
Tim Rattay
Mohammed Mustafa
ResearchOpen Access29 Mar 2019
British Journal of Cancer

Volume: 120, P: 883-895