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Showing 1–2 of 2 results
Advanced filters: Author: Kristof van Avondt Clear advanced filters

  • Anisimov, Fang et al. report that in humans, genetic variants associated with higher TIE2 expression are predicted to confer a reduced risk of CAD; in mice, Tie2 expression in endothelial cells is atheroprotective, and in a subset of aortic fibroblasts, anti-inflammatory.

    • Andrey Anisimov
    • Shentong Fang
    • Kari Alitalo
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 307-321

  • Intravascular haemolysis and the subsequent release of proinflammatory haemoglobin and haem into the circulation are characteristic of several diseases. This Review discusses the major pathophysiological mechanisms and consequences of intravascular haemolysis with a focus on the kidney, and highlights emerging therapeutic strategies to target haemolysis-related kidney injury.

    • Kristof Van Avondt
    • Erfan Nur
    • Sacha Zeerleder
    Reviews
    Nature Reviews Nephrology
    Volume: 15, P: 671-692