Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Kristopher Bosse Clear advanced filters

  • The native anaplastic lymphoma kinase (ALK) oncofetal protein is expressed in neuroblastoma and in multiple pediatric and adult solid tumors. Here, the authors show an ALK-directed antibody-drug conjugate with therapeutic efficacy in ALK-expressing preclinical models.

    • Alberto D. Guerra
    • Smita Matkar
    • Yael P. Mossé
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • GPC2 and GD2 have been described as immunotherapeutic targets in neuroblastoma. Here the authors engineer T cells to simultaneously express a GPC2-directed CAR and a bispecific innate immune cell engager targeting GD2 and CD16a, showing antitumor activity in neuroblastoma preclinical models.

    • Guillem Pascual-Pasto
    • Brendan McIntyre
    • Kristopher R. Bosse
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Here, single nucleotide variants within the LMO1 locus are shown to be associated with inherited susceptibility to neuroblastoma, a childhood cancer of the sympathetic nervous system. Acquired structural variation in the same locus was also frequently found in neuroblastoma patients, leading to the suggestion that loci identified through genome-wide association studies might be also prone to somatic alterations and therefore identify potential therapy targets and/or biomarkers of tumour aggressiveness.

    • Kai Wang
    • Sharon J. Diskin
    • John M. Maris
    Research
    Nature
    Volume: 469, P: 216-220

  • John Maris and colleagues report results of a genome-wide association and replication study for aggressive neuroblastoma. They show that common variants in the BARD1 locus at 2q35 are strongly associated with the disease.

    • Mario Capasso
    • Marcella Devoto
    • John M Maris
    Research
    Nature Genetics
    Volume: 41, P: 718-723

  • Peptide-centric chimeric antigen receptors (PC-CARs) provide a platform to address the challenges involved in targeting intracellular oncoproteins, and PC-CARs based on the neuroblastoma-dependency gene PHOX2B induce elimination of aggressive tumors.

    • Mark Yarmarkovich
    • Quinlen F. Marshall
    • John M. Maris
    ResearchOpen Access
    Nature
    Volume: 623, P: 820-827

  • Copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) are two important potential sources of phenotypic variation in humans; however, only SNPs have been associated with cancer. Here, a CNV at 1q21.1 is shown to be associated with neuroblastoma, and a transcript within this CNV, NBPF23, is implicated in early tumorigenesis of the disease.

    • Sharon J. Diskin
    • Cuiping Hou
    • John M. Maris
    Research
    Nature
    Volume: 459, P: 987-991