Nature Search

Mouse models of neutropenia reveal progenitor-stage-specific defects

Mouse models of severe congenital neutropenia using patient-derived mutations in the GFI1 locus are used to determine the mechanisms by which the disease progresses.

David E. Muench
Andre Olsson
H. Leighton Grimes
Research22 Apr 2020
Nature

Volume: 582, P: 109-114
Adult mice generated from induced pluripotent stem cells

Differentiated cells can be reprogrammed into induced pluripotent stem (iPS) cells through the transient overexpression of a small number of transcription factors. These iPS cells resemble embryonic stem (ES) cells but, until now, they had not passed the most stringent test of pluripotency by generating full-term or adult mice in tetraploid complementation assays. Here, fertile adult mice derived entirely from iPS cells are reported.

Michael J. Boland
Jennifer L. Hazen
Kristin K. Baldwin
Research02 Aug 2009
Nature

Volume: 461, P: 91-94
Joint probabilistic modeling of single-cell multi-omic data with totalVI

Total Variational Inference is a framework for end-to-end analysis of paired transcriptome and protein measurements such as CITE-seq data in single cells.

Adam Gayoso
Zoë Steier
Nir Yosef
Research15 Feb 2021
Nature Methods

Volume: 18, P: 272-282
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells

Chromatin accessibility, gene expression and protein levels are measured in the same single cell.

Eleni P. Mimitou
Caleb A. Lareau
Peter Smibert
Research03 Jun 2021
Nature Biotechnology

Volume: 39, P: 1246-1258
Whole-genome mutational burden analysis of three pluripotency induction methods

It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential.

Kunal Bhutani
Kristopher L. Nazor
Jeanne F. Loring
ResearchOpen Access19 Feb 2016
Nature Communications

Volume: 7, P: 1-8
SCITO-seq: single-cell combinatorial indexed cytometry sequencing

Single-cell combinatorial indexed cytometry sequencing (SCITO-seq) combines split-pool indexing and droplet-based single-cell sequencing for single-cell protein profiling.

Byungjin Hwang
David S. Lee
Chun Jimmie Ye
Research05 Aug 2021
Nature Methods

Volume: 18, P: 903-911
Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Induced pluripotent stem cells are shown to be useful for studying phenotypes relevant to familial and sporadic Alzheimer’s disease, even though it can take decades for the disease to manifest in patients.

Mason A. Israel
Shauna H. Yuan
Lawrence S. B. Goldstein
Research25 Jan 2012
Nature

Volume: 482, P: 216-220
Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis

Yu-Chieh Wang
Masato Nakagawa
Jeanne F Loring
ResearchOpen Access06 Sept 2011
Cell Research

Volume: 21, P: 1551-1563

Search

Filter By:

Search

Quick links