Glucocorticoid receptor (GR) binds as a dimer to DNA, with the canonical binding sequence featuring two half-sites, each bound by one monomer, separated by a 3-bp spacer. The specific bases contacted by GR are known to direct receptor activity. Now NMR and functional analyses show that nonspecific interactions, including with the spacer region, can also affect GR conformation and activity.
- Lisa C Watson
- Kristopher M Kuchenbecker
- Keith R Yamamoto
