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Showing 1–2 of 2 results
Advanced filters: Author: Krutika Satish Gaonkar Clear advanced filters

  • Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival.

    • Gwen Lomberk
    • Yuna Blum
    • Raul Urrutia
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor suppressor gene silencing.

    • Sergey Karakashev
    • Hengrui Zhu
    • Rugang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11