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Showing 1–3 of 3 results
Advanced filters: Author: Kshitij Mankad Clear advanced filters

  • Federated learning (FL) has emerged as a potential solution to train machine learning models in multiple clinical datasets while preserving patient privacy. Here, the authors develop an MRI-based FL platform for pediatric posterior fossa brain tumors—FL-PedBrain—and evaluate it on a diverse multi-center cohort.

    • Edward H. Lee
    • Michelle Han
    • Kristen W. Yeom
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Multi-omic mapping shows that group 3 and group 4 medulloblastomas have a common, human-specific developmental origin in the cerebellar rhombic lip, providing a basis for their ambiguous molecular features and overlapping anatomical location, and for the difficulty of modelling these tumours in mice.

    • Kyle S. Smith
    • Laure Bihannic
    • Paul A. Northcott
    Research
    Nature
    Volume: 609, P: 1012-1020

  • Genetic variants in ionotropic glutamate receptors have been implicated in neurodevelopmental disorders. Here, the authors report heterozygous de novo mutations in the GRIA2 gene in 28 individuals with intellectual disability and neurodevelopmental abnormalities associated with reduced Ca2+ transport and AMPAR currents.”

    • Vincenzo Salpietro
    • Christine L. Dixon
    • Henry Houlden
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16