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Showing 1–3 of 3 results
Advanced filters: Author: Kumari Sonal Choudhary Clear advanced filters

  • Single-cell RNAseq can struggle to capture cellular heterogeneity due to the relatively low expression of biologically meaningful transcripts. Here the authors present an approach called scCLEAN, which uses CRISPR/Cas9 to target and remove certain ubiquitous transcripts, thereby enhancing the detection of low-abundance transcripts.

    • Amitabh C. Pandey
    • Jon Bezney
    • Eric J. Topol
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Adaptive laboratory evolution experiments in Escherichia coli show that the pseudogene efeU can be repaired to restore the bacterium’s iron uptake system, demonstrating that pseudogenes may serve as an ‘adaptive repertoire’ of selectable traits.

    • Amitesh Anand
    • Connor A. Olson
    • Bernhard O. Palsson
    Research
    Nature Microbiology
    Volume: 4, P: 386-389

  • Mechanistic insight into the regulation of transcriptional modules remains scarce. Here, the authors identify statistically independent gene sets by applying independent component analysis to a high-quality E. coli RNA-seq data compendium and find that most gene sets represent the effects of specific transcriptional regulators.

    • Anand V. Sastry
    • Ye Gao
    • Bernhard O. Palsson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14