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Advanced filters: Author: Kumiko Makide Clear advanced filters

  • A G protein–coupled receptor (GPCR) signaling assay based on ectodomain shedding of a membrane-bound proform of alkaline phosphatase-tagged TGFα provides a platform for studying poorly characterized Gα12/13-coupled GPCRs. The assay allowed identification of three orphan GPCRs as Gα12/13-coupled lysophosphatidylserine receptors.

    • Asuka Inoue
    • Jun Ishiguro
    • Junken Aoki
    Research
    Nature Methods
    Volume: 9, P: 1021-1029