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Scientific Reports (13)
Journal of Human Genetics (11)
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Showing 1–50 of 67 results

Advanced filters: Author: Kunihiro Matsumoto Clear advanced filters

New human gene encoding a positive modulator of HIV Tat-mediated transactivation

Hiroshi Shibuya
Kenji Irie
Kunihiro Matsumoto
Research25 Jun 1992
Nature

Volume: 357, P: 700-702
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

Kunihiro Yoshida
Kenichi Furihata
Nobuo Yanagisawa
Research01 Mar 1995
Nature Genetics

Volume: 9, P: 267-272
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Atsushi Matsuzawa
Kaoru Saegusa
Hidenori Ichijo
Research01 May 2005
Nature Immunology

Volume: 6, P: 587-592
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease

Akira Kinoshita
Takashi Saito
Koh-ichiro Yoshiura
Research01 Sept 2000
Nature Genetics

Volume: 26, P: 19-20
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Erratum: A histone lysine methyltransferase activated by non-canonical Wnt signalling supresses PPAR-γ transactivation

Ichiro Takada
Masatomo Mihara
Shigeaki Kato
Amendments and Corrections30 Nov 2012
Nature Cell Biology

Volume: 14, P: 1345
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Retraction Note: A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation

Ichiro Takada
Masatomo Mihara
Shigeaki Kato
Amendments and Corrections31 Oct 2014
Nature Cell Biology

Volume: 16, P: 1126
Retraction Note: Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade

Miyuki Suzawa
Ichiro Takada
Shigeaki Kato
Amendments and Corrections31 Oct 2014
Nature Cell Biology

Volume: 16, P: 1126
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

Tohru Ishitani
Jun Ninomiya-Tsuji
Kunihiro Matsumoto
Research24 Jun 1999
Nature

Volume: 399, P: 798-802
Late-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation

Hiroshi Doi
Masao Ushiyama
Kunihiro Yoshida
ResearchOpen Access24 Nov 2014
Scientific Reports

Volume: 4, P: 1-7
Rheology of Copolymer Solutions. IV. Nonlinear Viscoelasticity of Solutions of an SBS Block Copolymer

Kunihiro Osaki
Bong-Shik Kim
Michio Kurata
Research01 Jan 1979
Polymer Journal

Volume: 11, P: 33-42
A shift of the TOR adaptor from Rictor towards Raptor by semaphorin in C. elegans

What controls the binding partner selection of the target of rapamycin protein, TOR, is unknown. Using theCaenorhabditis elegans tail as a model, Nukazuka et al. determine that signals of semaphorin through plexin control the binding partner selection of TOR and are required for the correct organization of rays in the tail.

Akira Nukazuka
Shusaku Tamaki
Shin Takagi
ResearchOpen Access27 Sept 2011
Nature Communications

Volume: 2, P: 1-10
Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade

Miyuki Suzawa
Ichiro Takada
Shigeaki Kato
Research24 Feb 2003
Nature Cell Biology

Volume: 5, P: 224-230
The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

Mineo Kurokawa
Kinuko Mitani
Hisamaru Hirai
Research01 Jul 1998
Nature

Volume: 394, P: 92-96
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

Jun Ninomiya-Tsuji
Kazuya Kishimoto
Kunihiro Matsumoto
Research18 Mar 1999
Nature

Volume: 398, P: 252-256
An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans

Kiyoji Nishiwaki
Yukihiko Kubota
Kunihiro Matsumoto
Research21 Dec 2003
Nature Cell Biology

Volume: 6, P: 31-37
Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing

Takashi Adachi-Yamada
Konomi Fujimura-Kamada
Kunihiro Matsumoto
Research08 Jul 1999
Nature

Volume: 400, P: 166-169
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans

Marc D. Meneghini
Tohru Ishitani
Bruce Bowerman
Research24 Jun 1999
Nature

Volume: 399, P: 793-797
Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability

Tohru Ishitani
Kunihiro Matsumoto
Motoyuki Itoh
Research16 Oct 2005
Nature Cell Biology

Volume: 7, P: 1106-1112
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning

Hiroshi Hanafusa
Kunihiro Matsumoto
Eisuke Nishida
Research02 Jan 2009
Nature Cell Biology

Volume: 11, P: 106-109
Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor

Activation of the epidermal growth factor receptor can result in its internalization and subsequent intracellular trafficking. In this study, the authors show that leucine-rich repeat kinase-1 can bind to the receptor and regulate its trafficking between different endosomal compartments.

Hiroshi Hanafusa
Kouki Ishikawa
Kunihiro Matsumoto
ResearchOpen Access18 Jan 2011
Nature Communications

Volume: 2, P: 1-12
Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

The molecular mechanism of axon regeneration after injury is poorly understood. Here the authors show that in C. elegans, the HIF-1 transcription factor induces ectopic synthesis of serotonin in severed ‘non-serotonergic’ neurons and that serotonin activates downstream signaling pathways leading to axon regeneration.

Tanimul Alam
Hiroki Maruyama
Kunihiro Matsumoto
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-11
Endocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signalling

Axon regeneration inC. elegansis positively regulated by the JNK/MAP kinase pathway. Pastuhov and colleagues identify the endocannabinoid anandamide as a negative regulator of this pathway and show that anandamide inhibits axon regeneration in mature neurons after axotomy.

Strahil Iv. Pastuhov
Kota Fujiki
Naoki Hisamoto
ResearchOpen Access16 Oct 2012
Nature Communications

Volume: 3, P: 1-9
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation

Ichiro Takada
Masatomo Mihara
Shigeaki Kato
Research21 Oct 2007
Nature Cell Biology

Volume: 9, P: 1273-1285
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Essential function for the kinase TAK1 in innate and adaptive immune responses

Shintaro Sato
Hideki Sanjo
Shizuo Akira
Research25 Sept 2005
Nature Immunology

Volume: 6, P: 1087-1095
The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade

Following axonal injury in C. elegans, the growth factor SVH-1 and its cognate receptor tyrosine kinase, SVH-2, act to promote axonal regeneration via activation of the JNK-MAPK pathway.

Chun Li
Naoki Hisamoto
Kunihiro Matsumoto
Research04 Mar 2012
Nature Neuroscience

Volume: 15, P: 551-557
Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration

Apoptotic cells display surface signals such as phosphatidlyserines that are recognized by phagocytes via engulfment signal receptors. Here, the authors show how one such receptor, transthyretin-like protein 11, plays a role in initiating axon regeneration in the peripheral nervous system.

Naoki Hisamoto
Anna Tsuge
Kunihiro Matsumoto
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-11
PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2

Hanafusa and Matsumato and colleagues find that LRRK1 is a substrate for PLK1 in mitosis. Phosphorylated LRRK1 in turn phosphorylates CDK5RAP2 to promote centrosomal microtubule nucleation and correct spindle orientation.

Hiroshi Hanafusa
Shin Kedashiro
Kunihiro Matsumoto
Research20 Jul 2015
Nature Cell Biology

Volume: 17, P: 1024-1035
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms

Yoshihiro Onouchi
Tomohiko Gunji
Akira Hata
Research16 Dec 2007
Nature Genetics

Volume: 40, P: 35-42
Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics

Masakazu Morioka
Yoshihiro Takamura
Masaru Inatani
ResearchOpen Access17 Dec 2020
Scientific Reports

Volume: 10, P: 1-6
Functional and anatomical changes in diabetic macular edema after hemodialysis initiation: One-year follow-up multicenter study

Yoshihiro Takamura
Takehiro Matsumura
Masaru Inatani
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-8
A −16C>T substitution in the 5′ UTR of the puratrophin-1 gene is prevalent in autosomal dominant cerebellar ataxia in Nagano

Takako Ohata
Kunihiro Yoshida
Naomichi Matsumoto
Research01 May 2006
Journal of Human Genetics

Volume: 51, P: 461-466
Relationship between the lower limit of systolic blood pressure target and kidney function decline in advanced chronic kidney disease: an instrumental variable analysis from the REACH-J CKD cohort study

Shimon Kurasawa
Yoshinari Yasuda
Kiyoyuki Tokuyama
Research18 Jul 2023
Hypertension Research

Volume: 46, P: 2478-2487
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Rheology of Copolymer Solutions. III. The Linear Viscoelasticity of SBS Block Copolymer Solutions

Kunihiro Osaki
Bong-Shik Kim
Michio Kurata
Research01 May 1978
Polymer Journal

Volume: 10, P: 353-363
Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex

Notch-mediated transcriptional activation requires the formation of a ternary complex, consisting of NotchICD, CSL and a Mastermind family member. Nemo-like kinase is shown to negatively regulate Notch signalling and to promote neurogenesis in zebrafish by phosphoprylating Notch1ICD and reducing formation of the ternary complex.

Tohru Ishitani
Tomoko Hirao
Motoyuki Itoh
Research31 Jan 2010
Nature Cell Biology

Volume: 12, P: 278-285
Regional features of autosomal-dominant cerebellar ataxia in Nagano: clinical and molecular genetic analysis of 86 families

Yusaku Shimizu
Kunihiro Yoshida
Shu-ichi Ikeda
Research01 Nov 2004
Journal of Human Genetics

Volume: 49, P: 610-616
Nationwide survey on predictive genetic testing for late-onset, incurable neurological diseases in Japan

Kunihiro Yoshida
Takahito Wada
Yoshimitsu Fukushima
Research05 Jul 2007
Journal of Human Genetics

Volume: 52, P: 675-679
Predominant cerebellar phenotype in spastic paraplegia 7 (SPG7)

Hiroyuki Yahikozawa
Kunihiro Yoshida
Naomichi Matsumoto
ResearchOpen Access26 Mar 2015
Human Genome Variation

Volume: 2, P: 1-3
A novel frameshift mutation of SYNE1 in a Japanese family with autosomal recessive cerebellar ataxia type 8

Tsuneaki Yoshinaga
Katsuya Nakamura
Yoshiki Sekijima
ResearchOpen Access26 Oct 2017
Human Genome Variation

Volume: 4, P: 1-4
Follow-up nationwide survey on predictive genetic testing for late-onset hereditary neurological diseases in Japan

Keiko Tanaka
Yoshiki Sekijima
Yoshimitsu Fukushima
Research02 May 2013
Journal of Human Genetics

Volume: 58, P: 560-563
Rapid and comprehensive diagnostic method for repeat expansion diseases using nanopore sequencing

Satoko Miyatake
Eriko Koshimizu
Naomichi Matsumoto
ResearchOpen Access26 Oct 2022
npj Genomic Medicine

Volume: 7, P: 1-15
A Japanese case of SCA14 with the Gly128Asp mutation

Hiroshi Morita
Kunihiro Yoshida
Shu-ichi Ikeda
Research01 Dec 2006
Journal of Human Genetics

Volume: 51, P: 1118-1121

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