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Showing 1–15 of 15 results
Advanced filters: Author: Kurt V. Gothelf Clear advanced filters

  • DNA based sensors provide substantial amounts of information that requires integration and processing. Here the authors demonstrate a DNA-based calculator that takes two inputs, identifies the solution in a library of answers and displays the result.

    • Huajie Liu
    • Jianbang Wang
    • Kurt V. Gothelf
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • The poor bench stability of phosphoramidites is a drawback for fast automised chemical oligonucleotide synthesis. Here, the authors report a method for on-demand flow synthesis of phosphoramidites within short reaction times, in near-quantitative yields and sufficient purity for integration with DNA synthesizers.

    • Alexander F. Sandahl
    • Thuy J. D. Nguyen
    • Kurt V. Gothelf
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-7

  • By exploiting the unique structural motifs and self-recognition properties of DNA, it is possible to generate self-assembled DNA nanostructures of specific shapes. Here, a previously described DNA 'origami' method has been extended into three dimensions to create an addressable DNA box on the nanometre scale that can be opened by an externally supplied DNA key'.

    • Ebbe S. Andersen
    • Mingdong Dong
    • Jørgen Kjems
    Research
    Nature
    Volume: 459, P: 73-76

  • A DNA walker moving along a DNA track can perform a series of organic reactions in a single solution without external intervention.

    • Alexandru Rotaru
    • Kurt V. Gothelf
    News & Views
    Nature Nanotechnology
    Volume: 5, P: 760-761

  • Bond-cleavage and bond-forming reactions can be performed at local positions on a DNA origami scaffold and imaged at the single-molecule level with atomic force microscopy.

    • Niels V. Voigt
    • Thomas Tørring
    • Kurt Vesterager Gothelf
    Research
    Nature Nanotechnology
    Volume: 5, P: 200-203

  • Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.

    • Jacob Lauwring Andersen
    • Borbala Gesser
    • Poul Nissen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • Conjugation of DNA to proteins often involves a choice between either expressing recombinant proteins with a specific handle, or labelling wild-type proteins with low site-selectivity. Now preorganization of a DNA–ligand complex to a metal-binding site enables site-selective conjugation of a DNA strand to lysine residues of wild-type proteins and antibodies.

    • Christian B. Rosen
    • Anne L. B. Kodal
    • Kurt V. Gothelf
    Research
    Nature Chemistry
    Volume: 6, P: 804-809

  • DNA origami has gained great interest for the creation of precise nanostructures. Here, the authors report on the creation of metalized DNA origami structured formed by metal condensation of DNA and nucleated metal growth on the formed DNA nanostructures.

    • Sisi Jia
    • Jianbang Wang
    • Chunhai Fan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Synthetic polymer wires, which contain short oligonucleotides extending from each repeat, can assemble into predesigned routings on two- and three-dimensional DNA origami templates.

    • Jakob Bach Knudsen
    • Lei Liu
    • Kurt V. Gothelf
    Research
    Nature Nanotechnology
    Volume: 10, P: 892-898

  • FRET has been used to study protein conformational changes but has never been applied to RNA aptamers. Here the authors develop a genetically encodable RNA aptamer-based FRET system on single-stranded RNA origami scaffolds, and demonstrate it can be used to study RNA conformational changes.

    • Mette D. E. Jepsen
    • Steffen M. Sparvath
    • Ebbe S. Andersen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Dey et al. discuss the design and implementation of DNA origami, as well as the techniques used to analyse quality and construction. They summarize exciting new research areas where DNA nanotechnology is being used and future directions for the field.

    • Swarup Dey
    • Chunhai Fan
    • Pengfei Zhan
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-24