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Showing 1–4 of 4 results
Advanced filters: Author: Kwangbom Choi Clear advanced filters

  • Allele-specific expression at single-cell resolution can reveal stochastic and dynamic features of gene expression in greater detail. The authors propose scBASE, a soft zero-and-one inflated model that improves estimation of cellular allelic proportions by pooling information across cells.

    • Kwangbom Choi
    • Narayanan Raghupathy
    • Gary A. Churchill
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The effect of natural genetic diversity on the proteome is characterized using an outbred mouse model with extensive variation; both transcripts and proteins from mouse livers are quantified to identify a large set of protein quantitative trait loci (pQTL), and mediation analysis identifies causal protein intermediates of distant pQTL.

    • Joel M. Chick
    • Steven C. Munger
    • Steven P. Gygi
    Research
    Nature
    Volume: 534, P: 500-505

  • Human population genomic studies, including whole‐genome sequencing, were undertaken to identify determinants of bone mineral density (BMD), a major predictor of osteoporotic fractures. Non‐coding variants with large effects on BMD and fractures were identified near the EN1 locus and mouse studies confirmed this gene has an important role in skeletal biology.

    • Hou‐Feng Zheng
    • Vincenzo Forgetta
    • J. Brent Richards
    Research
    Nature
    Volume: 526, P: 112-117