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Showing 1–3 of 3 results
Advanced filters: Author: Kyosuke Shinohara Clear advanced filters

  • The left–right asymmetry of an organism is patterned during development and is determined by fluid flow created by the movement of cilia. In this study, the asymmetry is shown to be determined early after the movement of cilia is established and that only two rotating cilia are required for breaking symmetry.

    • Kyosuke Shinohara
    • Aiko Kawasumi
    • Hiroshi Hamada
    Research
    Nature Communications
    Volume: 3, P: 1-8

  • During embryonic development, midline fluid flow results in asymmetric nodal gene expression. Using genetic manipulations and mathematical modelling, Nakamura et al. find that expression of the nodal antagonist Cerl2 is regulated post-transcriptionally, and that asymmetry is maintained by Wnt-Cerl2 feedback loops.

    • Tetsuya Nakamura
    • Daisuke Saito
    • Hiroshi Hamada
    Research
    Nature Communications
    Volume: 3, P: 1-13

  • Mouse node cilia are posteriorly tilted to generate a leftward fluid flow and left/right asymmetry in the embryo, but how the tilt comes about was not known. The basal bodies of node cilia gradually shift from a central position towards the posterior side of node cells in a dishevelled and non-canonical Wnt signalling-dependent manner and follow a shift in Dvl localization to the posterior.

    • Masakazu Hashimoto
    • Kyosuke Shinohara
    • Hiroshi Hamada
    Research
    Nature Cell Biology
    Volume: 12, P: 170-176