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Showing 1–2 of 2 results
Advanced filters: Author: Kyoung-Wook Moon Clear advanced filters
  • MORC2, a chromatin remodeler involved in epigenetic silencing and DNA repair, is linked to cancer and neurological disorders when dysregulated. Here, the authors show that MORC2 binds DNA at multiple sites, clamps onto it, and induces compaction, a process regulated by its phosphorylation.

    • Winnie Tan
    • Jeongveen Park
    • Shabih Shakeel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22
  • This Perspective discusses DNA-loop extrusion generated by SMC. The model details how the “DNA baton” is transferred from the hinge domain to a DNA pocket through anisotropic hinge motion, ensuring loop stability and providing insights into the dynamic process of DNA-loop extrusion.

    • Kyoung-Wook Moon
    • Do-Gyun Kim
    • Je-Kyung Ryu
    ReviewsOpen Access
    Communications Biology
    Volume: 7, P: 1-7