Traditional synthetic biology tools operate by complex re-programming of DNA, requiring significant amount of ‘nucleotide-based code’ to implement instructions that are transcribed at the protein level. Here the authors demonstrate the direct regulation of cellular phenotype at the single-protein level by creating a two-input logic gate for biological computation using ‘allosteric wiring’.
- Yashavantha L. Vishweshwaraiah
- Jiaxing Chen
- Nikolay V. Dokholyan
