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Showing 101–150 of 552 results

Advanced filters: Author: L L Knowles Clear advanced filters

Solution structure of the cyclosporin A/cyclophilin complex by NMR

Yves Thériault
Timothy M. Logan
Stephen W. Fesik
Research07 Jan 1993
Nature

Volume: 361, P: 88-91
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship

Sherif E. Gabriel
Lane L. Clarke
M. Jackson Stutts
Research20 May 1993
Nature

Volume: 363, P: 263-266
Control of H-2 expression in transformed nonhaemopoietic cells by autocrine interferon

P Nanni
L Landuzzi
P-L Lollini
Research01 Sept 1992
British Journal of Cancer

Volume: 66, P: 479-482
Pauling's model not universally accepted

ALAN L. MACKAY
Research09 Jan 1986
Nature

Volume: 319, P: 103-104
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Macrophages synthesise and release prostaglandins in response to inflammatory stimuli

J. L. HUMES
R. J. BONNEY
P. DAVIES
Research01 Sept 1977
Nature

Volume: 269, P: 149-151
A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex

A. M. Brzozowski
U. Derewenda
L. Thim
Research06 Jun 1991
Nature

Volume: 351, P: 491-494
Calcium and magnesium ions and the regulation of multiplication in normal and transformed cells

W. L. MCKEEHAN
R. G. HAM
Research26 Oct 1978
Nature

Volume: 275, P: 756-758
Graft-versus-leukaemia reactivity induced by alloimmunisation without augmentation of graft-versus-host reactivity

Mortimer M. Bortin
Robert L. Truitt
Fritz H. Bach
Research11 Oct 1979
Nature

Volume: 281, P: 490-491
Implications of fragile X expression in normal males for the nature of the mutation

David H. Ledbetter
Susan A. Ledbetter
Robert L. Nussbaum
Research13 Nov 1986
Nature

Volume: 324, P: 161-163
Disentangling the genetic effects of refugial isolation and range expansion in a trans-continentally distributed species

B. N. Reid
J. M. Kass
E. Naro-Maciel
Research31 Aug 2018
Heredity

Volume: 122, P: 441-457
Peripheral deletion of antigen-reactive T cells in oral tolerance

Youhai Chen
Jun-ichi Inobe
Howard L. Weiner
Research13 Jul 1995
Nature

Volume: 376, P: 177-180
HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas

Ashlee V. Moses
Sally E. Williams
Jay A. Nelson
Research01 Nov 1997
Nature Medicine

Volume: 3, P: 1242-1249
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, several of which show stronger effects in women than in men.

Iris M Heid
Anne U Jackson
Cecilia M Lindgren
Research10 Oct 2010
Nature Genetics

Volume: 42, P: 949-960
Single-molecule digital sizing of proteins in solution

Physical characterisation of proteins is challenging. Here the authors report single-molecule microfluidic diffusional sizing (smMDS) to enable calibration-free single-molecule diffusional-sizing based monitoring of protein hydrodynamic radii even within heterogenous multicomponent mixtures.

Georg Krainer
Raphael P. B. Jacquat
Tuomas P. J. Knowles
ResearchOpen Access04 Sept 2024
Nature Communications

Volume: 15, P: 1-19
Assuming the mantle of soothsayer

L. Knopoff
Books & Arts23 Sept 1976
Nature

Volume: 263, P: 355
Evolutionary origin and population diversity of a cryptic hybrid pathogen

Characterization of clinical isolates of the cryptic fungal pathogen Aspergillus latus revealed traits that distinguish it from other species. Steenwyck et al show that A. latus originated via allodiploid hybridization with both parental subgenomes actively expressed.

Jacob L. Steenwyk
Sonja Knowles
Antonis Rokas
ResearchOpen Access28 Sept 2024
Nature Communications

Volume: 15, P: 1-16
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Intracellular recorded synaptic antagonism in the rat dentate gyrus

Vincenzo Crunelli
Susan Forda
John S. Kelly
Research02 Dec 1982
Nature

Volume: 300, P: 450-452
Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas

L Maouche-Chrétien
N Deleu
K Leroy-Viard
Research14 Sept 1998
Oncogene

Volume: 17, P: 1245-1251
Recessive mutations in the gene encoding the tubby-like protein TULP1 in patients with Retinitis pigmentosa

Stephanie A. Hagstrom
Michael A. North
Thaddeus P. Dryja
Research01 Feb 1998
Nature Genetics

Volume: 18, P: 174-176
Culture of human malaria parasites Plasmodium falciparum

J. DAVID HAYNES
CARTER L. DIGGS
ROBERT E. DESJARDINS
Research28 Oct 1976
Nature

Volume: 263, P: 767-769
Conversion of a photon to an electrical signal by sudden polarisation in the N-retinylidene visual chromophore

L. SALEM
P. BRUCKMANN
Research11 Dec 1975
Nature

Volume: 258, P: 526-528
Loss of constitutional heterozygosity on chromosome 5q in hepatocellular carcinoma without cirrhosis

S-F Ding
NA Habib
JDA Delhanty
Research01 Dec 1991
British Journal of Cancer

Volume: 64, P: 1083-1087
Direct digital sensing of protein biomarkers in solution

There are limitations with current protein sensing methods. Here the authors report DigitISA, a digital immunosensor assay based on microchip electrophoretic separation and single-molecule detection that enables quantitation of protein biomarkers in a single, solution-phase step.

Georg Krainer
Kadi L. Saar
Tuomas P. J. Knowles
ResearchOpen Access06 Feb 2023
Nature Communications

Volume: 14, P: 1-21
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

Garry Cutting and colleagues report a genome-wide association and linkage study for loci that affect lung disease severity in cystic fibrosis. They identify two loci that influence lung function in individuals with cystic fibrosis.

Fred A Wright
Lisa J Strug
Garry R Cutting
Research22 May 2011
Nature Genetics

Volume: 43, P: 539-546
Protein Condensate Atlas from predictive models of heteromolecular condensate composition

Biomolecular condensates help cells organise their content in space and time. Here the authors report a machine learning driven methodology to predict the composition of biomolecular condensates and they then validate their predictions against the composition of known biomolecular condensates.

Kadi L. Saar
Rob M. Scrutton
Tuomas P. J. Knowles
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

Gene therapy in the inner ear achieves unprecedented recovery of hearing and balance behavior in Usher syndrome mice.

Bifeng Pan
Charles Askew
Gwenaëlle S Géléoc
Research06 Feb 2017
Nature Biotechnology

Volume: 35, P: 264-272
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conduction, rhythm disorders and cardiovascular disease. Their experimental studies in Drosophila melanogaster and zebrafish models provide support for a role for 20 candidate genes at 11 of these loci in regulation of heart rate.

Marcel den Hoed
Mark Eijgelsheim
Ruth J F Loos
Research14 Apr 2013
Nature Genetics

Volume: 45, P: 621-631
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Radio Communication in Arctic Regions

R. L. SMITH-ROSE
Research03 Apr 1965
Nature

Volume: 206, P: 53-54
Whole Body Protein Synthesis and Energy Expenditure in Very Low Birth Weight Infants

C Catzeflis
Y Schutz
E Jéquier
Research01 Jul 1985
Pediatric Research

Volume: 19, P: 679-687
Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors

E. David Leonardo
Lindsay Hinck
Marc Tessier-Lavigne
Research24 Apr 1997
Nature

Volume: 386, P: 833-838
Extracellular DNA traps in a ctenophore demonstrate immune cell behaviors in a non-bilaterian

Identifying core mechanisms of immune cells is critical for understanding the evolution of animal immune function. Here, Vandepas et al. report that ctenophore immune-like cells release extracellular DNA traps when exposed to microbes.

Lauren E. Vandepas
Caroline Stefani
Adam Lacy-Hulbert
ResearchOpen Access06 Apr 2024
Nature Communications

Volume: 15, P: 1-11
Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmission

J. G. R. Jefferys
H. L. Haas
Research02 Dec 1982
Nature

Volume: 300, P: 448-450
Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

Paul Cairns
Thomas J. Polascik
David Sidransky
Research01 Oct 1995
Nature Genetics

Volume: 11, P: 210-212
Removal of Xenon and Radon from Contaminated Atmospheres with Dioxygenyl Hexafluoroantimonate, O₂SbF₆

L. STEIN
Research04 May 1973
Nature

Volume: 243, P: 30-32
Metabolism of Nitrate Esters by a Consortium of Two Bacteria

Juan L. Ramos
Ali Haïdour
José-Miguel Oliva
Research01 Mar 1996
Nature Biotechnology

Volume: 14, P: 320-322
Inhibition by Arousal of Epilepsy Induced by Chlorambucil in Rats

JOHN P. J. PINEL
STEPHAN L. CHOROVER
Research31 Mar 1972
Nature

Volume: 236, P: 232-234
T-lymphocyte differentiation is accompanied by increase in sialic acid content of Thy-1 antigen

Daniel Hoessli
Claude Bron
J. Richard L. Pink
Research07 Feb 1980
Nature

Volume: 283, P: 576-578
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
P-chirogenic phosphorus compounds by stereoselective Pd-catalysed arylation of phosphoramidites

General and efficient methodologies for the construction of homochiral phosphorus stereocentres are sought-after. Now, merging Pd-catalysed cross-coupling with phosphorus arylation of phosphoramidites provides access to a broad array of asymmetric P-compounds by axial-to-central chirality transfer from BINOL.

Anirban Mondal
Niklas O. Thiel
Ben L. Feringa
Research23 Dec 2021
Nature Catalysis

Volume: 5, P: 10-19
A single generation of domestication heritably alters the expression of hundreds of genes

Little is known about the genetic underpinnings of the earliest stages of plant and animal domestication. Here, the authors show that steelhead trout respond to a single generation of domestication selection with large, heritable changes in expression of genes regulating immunity and metabolism.

Mark R. Christie
Melanie L. Marine
Michael S. Blouin
ResearchOpen Access17 Feb 2016
Nature Communications

Volume: 7, P: 1-6
Fine-scale genetic structure in Pinus clausa (Pinaceae) populations: effects of disturbance history

Kathleen C Parker
J L Hamrick
John D Nason
Research01 Jul 2001
Heredity

Volume: 87, P: 99-113
EXAFS study of the zinc-binding sites in the protein transcription factor IIIA

G. P. Diakun
L. Fairall
A. Klug
Research18 Dec 1986
Nature

Volume: 324, P: 698-699
Fluctuations and distribution of measles virus antigens in chronically infected cells

A. EHRNST
L. WEINER
E. NORRBY
Research19 Apr 1974
Nature

Volume: 248, P: 691-693
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Cystic fibrosis imposes a decline in quality of life but new treatments are being developed that target specificCFTRvariants. Here the authors identify five genome loci significantly associated with variation in disease severity in a meta-analysis, which may provide targets for individualized treatment of cystic fibrosis.

Harriet Corvol
Scott M. Blackman
Michael R. Knowles
ResearchOpen Access29 Sept 2015
Nature Communications

Volume: 6, P: 1-8
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Author Correction: Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues

Zijie Feng
Xin He
Xianxin Hua
Amendments and Corrections11 Apr 2024
Nature Cancer

Volume: 5, P: 691
Chemotherapy of Amœbicides *

F. L. Pyman
News13 Nov 1937
Nature

Volume: 140, P: 832-834

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