Nature Search

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a surrogate for brain accumulation of Aβ.

Xavier Hadoux
Flora Hui
Peter van Wijngaarden
ResearchOpen Access17 Sept 2019
Nature Communications

Volume: 10, P: 1-12
Single nucleus multi-omics regulatory landscape of the murine pituitary

The pituitary gland plays important roles in the regulation of key physiological functions. Here the authors provide a multiomics atlas including transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei (sn) from mouse pituitaries.

Frederique Ruf-Zamojski
Zidong Zhang
Stuart C. Sealfon
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-20
Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Adipose tissue varies depending on localization. Vijay et al. perform single-cell RNA sequencing in multiple adipose tissue depots from obese individuals and identify distinct subpopulations of endothelial cells, immune cells and pre-adipocytes.

Jinchu Vijay
Marie-Frédérique Gauthier
Elin Grundberg
Research23 Dec 2019
Nature Metabolism

Volume: 2, P: 97-109
Correction: Corrigendum: Genome-wide characterization of the routes to pluripotency

Samer M. I. Hussein
Mira C. Puri
Andras Nagy
Amendments and Corrections17 Jun 2015
Nature

Volume: 523, P: 626
The earliest dromaeosaurid theropod from South America

Peter J. Makovicky
Sebastián Apesteguía
Federico L. Agnolín
Research13 Oct 2005
Nature

Volume: 437, P: 1007-1011
The challenge of mapping the human connectome based on diffusion tractography

Though tractography is widely used, it has not been systematically validated. Here, authors report results from 20 groups showing that many tractography algorithms produce both valid and invalid bundles.

Klaus H. Maier-Hein
Peter F. Neher
Maxime Descoteaux
ResearchOpen Access07 Nov 2017
Nature Communications

Volume: 8, P: 1-13
Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Adam M. Staffaroni
Melanie Quintana
Sónia Afonso
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2194-2206
Aspects of the electrochemistry of steel in concrete

C. L. Page
K. W. J. Treadaway
Reviews13 May 1982
Nature

Volume: 297, P: 109-115
[¹⁸F]FDG PET signal is driven by astroglial glutamate transport

The identity of the cell types contributing to the [¹⁸F]FDG positron emission tomography signal remain highly controversial. In this study, the authors demonstrate that activating glutamate astrocytic transport increases brain [¹⁸F]FDG uptake. These findings indicate that astrocytes may also impact [¹⁸F]FDG positron emission tomography signal.

Eduardo R Zimmer
Maxime J Parent
Pedro Rosa-Neto
Research30 Jan 2017
Nature Neuroscience

Volume: 20, P: 393-395
Polymorphisms and environment: the adaptive value of the oil polymorphisms in Thymus vulgaris L.

P H Gouyon
Ph Vernet
G Valdeyron
Research01 Aug 1986
Heredity

Volume: 57, P: 59-66
Two-colour pump–probe experiments with a twin-pulse-seed extreme ultraviolet free-electron laser

Free-electron lasers are a powerful new tool for studying properties and transient states of matter. Here, the authors use a novel seed scheme for generation of two XUV laser pulses of controlled wavelength and time separation that enables access to ultrafast phenomena with elemental sensitivity.

E. Allaria
F. Bencivenga
M. Zangrando
ResearchOpen Access18 Sept 2013
Nature Communications

Volume: 4, P: 1-7
High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina

It has been thought that blue-yellow color opponent cells in the primate retina receive little input from rods. Here, the authors report that rod and cone signals are multiplexed in blue-yellow cells and that this may be the source of the blue hue bias in night vision.

Greg D Field
Martin Greschner
E J Chichilnisky
Research09 Aug 2009
Nature Neuroscience

Volume: 12, P: 1159-1164
Change and Decay

P. L. KROHN
Books & Arts09 Jul 1966
Nature

Volume: 211, P: 121-122
Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens

Melioidosis and glanders are multifaceted infections caused by gram-negative bacteria. Here, the authors synthesize a series of oligosaccharides that mimic the lipopolysaccharides present on the pathogens’ surface and use them to develop novel glycoconjugates for vaccine development.

Marielle Tamigney Kenfack
Marcelina Mazur
Charles Gauthier
ResearchOpen Access24 Jul 2017
Nature Communications

Volume: 8, P: 1-13
Aβ-induced vulnerability propagates via the brain’s default mode network

Amyloid-β (Aβ) deposition occurs in Alzheimer's disease but its relation to disease features such as local brain hypometabolism or cognitive decline is unclear. Here, the authors show that Aβ aggregation in the brain’s default mode network leads to hypometabolism in distant but functionally connected areas.

Tharick A. Pascoal
Sulantha Mathotaarachchi
Pedro Rosa-Neto
ResearchOpen Access04 Jun 2019
Nature Communications

Volume: 10, P: 1-13
Background of modern comet theory

Fred L. Whipple
Reviews02 Sept 1976
Nature

Volume: 263, P: 15-19
Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue

The mechanisms of episodic memory are not well understood. Here, the authors show that the reactivation of non-spatial information precedes the reactivation of spatial information, and that both are correlated with hippocampal sharp-wave ripples.

HaoRan Chang
Ingrid M. Esteves
Bruce L. McNaughton
ResearchOpen Access27 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Coherent control with a short-wavelength free-electron laser

Researchers demonstrate correlation of two colours (63.0 and 31.5 nm wavelengths) in a free-electron laser and control photoelectron angular distribution by adjusting phase with 3 attosecond resolution.

K. C. Prince
E. Allaria
M. Meyer
Research22 Feb 2016
Nature Photonics

Volume: 10, P: 176-179
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

Roger L Milne
Karoline B Kuchenbaecker
Jacques Simard
Research23 Oct 2017
Nature Genetics

Volume: 49, P: 1767-1778
Peking to Mandalay ¹

L. A. W.
News17 Dec 1908
Nature

Volume: 79, P: 193-194
Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability

Therriault et al. provide a framework for the individual-level interpretation of plasma biomarkers by determining their positive and negative predictive values for amyloid positron emission tomography status in relation to patient age and clinical symptoms.

Joseph Therriault
Shorena Janelidze
Pedro Rosa-Neto
ResearchOpen Access12 Nov 2024
Nature Aging

Volume: 4, P: 1529-1537
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

AMPK activation inhibits cardiac hypertrophy. Here the authors show that this occurs independently of previously proposed mechanisms and that AMPK controls the phosphorylation of the aminotransferase GFAT, thereby preventing cardiac hypertrophy through the reduction of protein O-GlcNAcylation.

Roselle Gélinas
Florence Mailleux
Luc Bertrand
ResearchOpen Access25 Jan 2018
Nature Communications

Volume: 9, P: 1-17
[Book Reviews]

L. S. GODDARD
Books & Arts10 Sept 1960
Nature

Volume: 187, P: 890-891
Widely tunable two-colour seeded free-electron laser source for resonant-pump resonant-probe magnetic scattering

Two-colour X-ray free electron laser is a powerful tool for pump–probe measurements, but currently constrained by limited tunability. Here, Ferrari et al. develop a configuration that allows tuning both the pump and the probe to specific electronic excitations, providing element selectivity.

Eugenio Ferrari
Carlo Spezzani
Maurizio Sacchi
ResearchOpen Access13 Jan 2016
Nature Communications

Volume: 7, P: 1-8
Genomic data in the All of Us Research Program

A study describes the release of clinical-grade whole-genome sequence data for 245,388 diverse participants by the All of Us Research Program and characterizes the properties of the dataset.

Alexander G. Bick
Ginger A. Metcalf
Joshua C. Denny
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 340-346
The Racing World and its Inhabitants

R. L.
Books & Arts04 Aug 1904
Nature

Volume: 70, P: 316-317
MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

Liver cirrhosis is characterised by extensive fibrosis of the liver, and understanding the underpinning immunological processes is important in designing intervention. Here authors show that Mucosal-Associated Invariant T cells are instrumental to controlling the balance between profibrogenic and restorative macrophages and inhibiting their activation might reverse liver fibrosis.

Morgane Mabire
Pushpa Hegde
Sophie Lotersztajn
ResearchOpen Access01 Apr 2023
Nature Communications

Volume: 14, P: 1-13
The Scientific Papers of the Honourable Henry Cavendish, F.R.S.

T. M. L.
Books & Arts01 Sept 1921
Nature

Volume: 108, P: 4-6
Mathematics

L. M. M.-T.
Books & Arts10 Mar 1934
Nature

Volume: 133, P: 369-370
APOEε4 potentiates amyloid β effects on longitudinal tau pathology

Ferrari-Souza et al. show that the APOEε4 allele potentiates the deleterious effects of Aβ on the longitudinal accumulation of tau tangles in neocortical brain regions, via tau phosphorylation, which coincides with brain atrophy and clinical decline.

João Pedro Ferrari-Souza
Bruna Bellaver
Tharick A. Pascoal
Research25 Sept 2023
Nature Aging

Volume: 3, P: 1210-1218
Observation of the rare B_s⁰ →µ⁺µ⁻ decay from the combined analysis of CMS and LHCb data

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

V. Khachatryan
A.M. Sirunyan
E. Pesen
ResearchOpen Access13 May 2015
Nature

Volume: 522, P: 68-72
Non-thermal melting in semiconductors measured at femtosecond resolution

A. Rousse
C. Rischel
D. Hulin
Research01 Mar 2001
Nature

Volume: 410, P: 65-68
Polar gigantism dictated by oxygen availability

Gauthier Chapelle
Lloyd S. Peck
Research13 May 1999
Nature

Volume: 399, P: 114-115
The Amphimedon queenslandica genome and the evolution of animal complexity

These authors report and analyse the draft genome sequence of the demosponge Amphimedon queenslandica. Sponges lie on the earliest branching lineage in the animal kingdom and thus have been important in studies of the origins of multicellularity. Comparative genomic analyses presented here provide significant insights into evolutionary origins of genes and pathways related to the hallmarks of metazoan multicellularity and to cancer biology.

Mansi Srivastava
Oleg Simakov
Daniel S. Rokhsar
ResearchOpen Access05 Aug 2010
Nature

Volume: 466, P: 720-726
The Paris Observatory¹

W. J. L.
News21 May 1891
Nature

Volume: 44, P: 70
Economics in the Light of War

A. L.
Books & Arts16 Nov 1916
Nature

Volume: 98, P: 208
Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation

L Xerri
R Bouabdallah
F Birg
Research01 Jul 1998
British Journal of Cancer

Volume: 78, P: 225-232
Femtosecond time-resolved X-ray diffraction from laser-heated organic films

Christian Rischel
Antoine Rousse
André Antonetti
Research04 Dec 1997
Nature

Volume: 390, P: 490-492
Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

In a new study including 200 families who experienced perinatal death, adding genomic analyses to standard autopsies improved the identification of underlying pathogenic causes and informed genetic counseling.

Alicia B. Byrne
Peer Arts
Hamish S. Scott
ResearchOpen Access19 Jan 2023
Nature Medicine

Volume: 29, P: 180-189
Wild Beasts of the World

R. L.
Books & Arts16 Sept 1909
Nature

Volume: 81, P: 332
Mitogenomes of mosquito species of Harris County in Texas

Renee L. M. N. Ali
Christian Gauthier
Douglas E. Norris
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Upstream open reading frames (uORFs), located in 5’ untranslated regions, are regulators of downstream protein translation. Here, Whiffin et al. use the genomes of 15,708 individuals in the Genome Aggregation Database (gnomAD) to systematically assess the deleteriousness of variants creating or disrupting uORFs.

Nicola Whiffin
Konrad J. Karczewski
James S. Ware
ResearchOpen Access27 May 2020
Nature Communications

Volume: 11, P: 1-12
Lower Attentional Skills predict increased exploratory foraging patterns

Charlotte Van den Driessche
Françoise Chevrier
Jérôme Sackur
ResearchOpen Access29 Jul 2019
Scientific Reports

Volume: 9, P: 1-7
Aufbau der zusammenhangenden Materie

L. F. B.
Books & Arts01 Dec 1935
Nature

Volume: 136, P: 973
Time-resolved RIXS experiment with pulse-by-pulse parallel readout data collection using X-ray free electron laser

H. Lu
A. Gauthier
W. S. Lee
ResearchOpen Access17 Dec 2020
Scientific Reports

Volume: 10, P: 1-7
Detection of circulating carcinoma cells by telomerase activity

L R Gauthier
C Granotier
F D Boussin
ResearchOpen Access27 Feb 2001
British Journal of Cancer

Volume: 84, P: 631-635
GATK-gCNV enables the discovery of rare copy number variants from exome sequencing data

GATK-gCNV uses a probabilistic model and inference framework to discover rare copy number variants (CNVs) from sequencing read-depth information. This algorithm is used to generate a reference catalog of rare coding CNVs in exome sequencing data from UK Biobank.

Mehrtash Babadi
Jack M. Fu
Michael E. Talkowski
Research21 Aug 2023
Nature Genetics

Volume: 55, P: 1589-1597
Statistical Year Book, 1937, of the International Tin Research and Development Council

L. D. S.
Books & Arts31 Jul 1937
Nature

Volume: 140, P: 176
Wild Life Conservation in Theory and Practice

R. L.
Books & Arts13 May 1915
Nature

Volume: 95, P: 281-282
The Under Dog: a Series of Papers by Various Authors on the Wrongs Suffered by Animals at the Hand of Man

R. L.
Books & Arts25 Sept 1913
Nature

Volume: 92, P: 94-95

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