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Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N²M² umbrella trial

In a phase 1/2a umbrella trial in patients with glioblastoma matching targeted therapies according to tumor molecular profiling, temsirolimus plus radiotherapy improved PFS compared to standard of care in patients with phospho-mTOR activation.

Wolfgang Wick
Lisa-Marie Lanz
Tobias Kessler
ResearchOpen Access05 Sept 2025
Nature Medicine

P: 1-8
BAFopathies’ DNA methylation epi-signatures demonstrate diagnostic utility and functional continuum of Coffin–Siris and Nicolaides–Baraitser syndromes

Mutations in genes encoding subunits of the BAF complex can cause Coffin–Siris and Nicolaides–Baraitser syndromes. Here the authors identify overlapping DNA methylation signatures in individuals with subtypes of these two syndromes that suggest a functional link and can be used to diagnose subjects with unclear clinical presentations.

Erfan Aref-Eshghi
Eric G. Bend
Bekim Sadikovic
ResearchOpen Access20 Nov 2018
Nature Communications

Volume: 9, P: 1-15
Correction: Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

Bekim Sadikovic
Michael A. Levy
Marielle Alders
Amendments and Corrections26 Feb 2021
Genetics in Medicine

Volume: 23, P: 2228
Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

Bekim Sadikovic
Michael A. Levy
Marielle Alders
ResearchOpen Access05 Feb 2021
Genetics in Medicine

Volume: 23, P: 1065-1074
The defining DNA methylation signature of Floating-Harbor Syndrome

Rebecca L. Hood
Laila C. Schenkel
Bekim Sadikovic
ResearchOpen Access09 Dec 2016
Scientific Reports

Volume: 6, P: 1-9

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Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial

BAFopathies’ DNA methylation epi-signatures demonstrate diagnostic utility and functional continuum of Coffin–Siris and Nicolaides–Baraitser syndromes

Correction: Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

The defining DNA methylation signature of Floating-Harbor Syndrome

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Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N²M² umbrella trial