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Developmental plasticity allows outside-in immune responses by resident memory T cells

Tissue-resident memory (T_RM) cells are generally stably maintained in discrete tissues or organs. Masopust and colleagues show that T_RM cells can reenter the circulation, and exhibit considerable plasticity, although they retain a proclivity to reestablish themselves in their tissue of origin.

Raissa Fonseca
Lalit K. Beura
David Masopust
Research17 Feb 2020
Nature Immunology

Volume: 21, P: 412-421
Expansible residence decentralizes immune homeostasis

Investigations in mice using parabiosis and cohousing experiments reveal that nonlymphoid organs serve as reservoirs of tissue-autonomous cellular immunity, leading to the decentralization of organism-level immune homeostasis.

Sathi Wijeyesinghe
Lalit K. Beura
David Masopust
Research17 Mar 2021
Nature

Volume: 592, P: 457-462
Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells

Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor antigen-specific CD8+ T cells and is associated with tissue residency and improved anti-tumor immune response in a preclinical model of prostate cancer.

Brandon J. Burbach
Stephen D. O’Flanagan
Yoji Shimizu
ResearchOpen Access23 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

The cytokine TGF-β maintains the residency of cells of the immune system in barrier tissues. Kaplan and colleagues demonstrate that specific integrins expressed by epithelial cells activate latent TGF-β and that this is critical to maintain residency of cells of the immune system in the skin and gut.

Javed Mohammed
Lalit K Beura
Daniel H Kaplan
Research22 Feb 2016
Nature Immunology

Volume: 17, P: 414-421
Monocyte-derived TGF-β shapes memory CD8+ T cells

Mohammad H. Hasan
Lalit K. Beura
Comments & Opinion10 Jul 2025
Cellular & Molecular Immunology

Volume: 22, P: 949-950
Intravital mucosal imaging of CD8⁺ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

Masopust and colleagues show that mucosal tissue-resident memory T cells proliferate in situ in response to local antigen and dominate the local recall response.

Lalit K. Beura
Jason S. Mitchell
David Masopust
Research08 Jan 2018
Nature Immunology

Volume: 19, P: 173-182
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8⁺ T cells

Activation of P2RX7 receptors by extracellular ATP is required for the generation, maintenance and function of central and tissue-resident CD8⁺ memory T cells.

Henrique Borges da Silva
Lalit K. Beura
Stephen C. Jameson
Research04 Jul 2018
Nature

Volume: 559, P: 264-268
Normalizing the environment recapitulates adult human immune traits in laboratory mice

The immune system of laboratory mice raised in an ultra-hygienic environment resembles that ofnewborn humans, but can be induced to resemble the immune system of adult humans or 'dirty' mice by co-housing with pet store-bought mice.

Lalit K. Beura
Sara E. Hamilton
David Masopust
Research20 Apr 2016
Nature

Volume: 532, P: 512-516
Intravascular staining for discrimination of vascular and tissue leukocytes

Kristin G Anderson
Katrin Mayer-Barber
David Masopust
Protocols02 Jan 2014
Nature Protocols

Volume: 9, P: 209-222

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