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Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor

Despite advances in GPCR structures and peptide design, creating high-affinity ligands remains a challenge. Here the authors develop a computational method, successfully identifying peptide-based molecules for KOR: their platform shows promise for streamlined GPCR ligand discovery.

Edin Muratspahić
Kristine Deibler
Christian W. Gruber
ResearchOpen Access06 Dec 2023
Nature Communications

Volume: 14, P: 1-17
Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

Gene regulation and metabolism co-ordinate self-renewal and differentiation of neural precursors (NPCs) in the developing brain. Here the authors show that methylglyoxal, a glycolytic intermediate metabolite, promotes GADPH-dependent translational repression of Notch1, thereby promoting NPC differentiation.

Deivid Carvalho Rodrigues
Emily M. Harvey
Guang Yang
ResearchOpen Access24 Apr 2020
Nature Communications

Volume: 11, P: 1-13
Mechanism of antagonist ligand binding to REV-ERBα

Mohammad Homaidur Rahman
Lamees Hegazy
ResearchOpen Access10 Apr 2024
Scientific Reports

Volume: 14, P: 1-10
Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

Sammy Alhassen, Siwei Chen, et al. use mouse models to examine the effects of prenatal and postnatal stress on metabolomic and transcriptomic pathways in the brain. Their results suggest that altered mitochondrial metabolism may underlie trauma-induced behavioral deficits, and that correcting metabolism with ALCAR supplementation may protect against intergenerational transmission of traumatic stress.

Sammy Alhassen
Siwei Chen
Amal Alachkar
ResearchOpen Access24 Jun 2021
Communications Biology

Volume: 4, P: 1-15
30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Rishi Singhal
Victor Roth Cardoso
Mehmet Saydam
ResearchOpen Access15 Dec 2021
International Journal of Obesity

Volume: 46, P: 750-757

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Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor

Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

Mechanism of antagonist ligand binding to REV-ERBα

Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

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