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Showing 1–5 of 5 results
Advanced filters: Author: Lars Burdorf Clear advanced filters

  • Xenotransplantation of a genetically edited pig kidney with a thymic autograft into a brain-dead human for 61 days with immunosuppression resulted in stable kidney function without proteinuria, and xenograft rejection was treated and reversed by the end of the study.

    • Robert A. Montgomery
    • Jeffrey M. Stern
    • Megan Sykes
    Research
    Nature
    Volume: 650, P: 218-229

  • Xenotransplantation is an imminent clinical reality but concerns remain around the logistics of procurement and the experimental immunosuppression regimens required to achieve long-term xenograft survival. Here the authors show more than 6 month survival of genetically modified porcine kidneys in baboons after regulatory compliant organ procurements, clinically relevant organ preservation times and FDA-approved immunosuppressive reagents.

    • Daniel Eisenson
    • Yu Hisadome
    • Kazuhiko Yamada
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-7

  • In a short-term study in which hearts from gene-edited pigs were transplanted into two recently deceased human recipients, the hearts were able to function for the duration of the study without signs of rejection and without evidence of pig virus transmission, encouraging further clinical study of cardiac xenotransplantation.

    • Nader Moazami
    • Jeffrey M. Stern
    • Robert A. Montgomery
    Research
    Nature Medicine
    Volume: 29, P: 1989-1997

  • An in situ imaging technique has been used to show that large rhizarian plankton represent a much larger biomass than previously thought, meaning that they are likely to make an important contribution to ocean ecosystems.

    • Tristan Biard
    • Lars Stemmann
    • Fabrice Not
    Research
    Nature
    Volume: 532, P: 504-507