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Showing 1–3 of 3 results
Advanced filters: Author: Lars Giger Clear advanced filters

  • A previously designed enzyme used a reactive lysine to initiate cleavage of a carbon-carbon bond. Directed evolution of this construct now shows a drastic reorganization of the active site to use an alternative catalytic lysine and suggests considerations for future design efforts.

    • Lars Giger
    • Sami Caner
    • Donald Hilvert
    Research
    Nature Chemical Biology
    Volume: 9, P: 494-498

  • Protein nanotechnology for the fabrication of protein-based nanoscale devices is gaining momentum but assembling well-defined three-dimensional shapes is still challenging. Here, the authors use an existing prefoldin assembled system to design a template for the construction of geometrically constrained structures.

    • Dominic J. Glover
    • Lars Giger
    • Douglas S. Clark
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9