Nature Search

Better results from prevention than from additional treatment

In 2015, success in clinical trials in heart failure was obtained mainly from prevention, whereas treatments showed neutral or even adverse effects. A new glucose-lowering medication prevents development of heart failure. Treating central sleep apnoea might be harmful. In Chagas cardiomyopathy, benznidazole treatment did not affect long-term clinical outcomes.

Lars Køber
News & Views04 Jan 2016
Nature Reviews Cardiology

Volume: 13, P: 75-77
Do ACE inhibitors improve outcome in patients with stable vascular disease?

Lars Køber
Christian Torp-Pedersen
Comments & Opinion23 Jan 2007
Nature Clinical Practice Cardiovascular Medicine

Volume: 4, P: 124-125
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.

Albert Henry
Xiaodong Mo
R. Thomas Lumbers
ResearchOpen Access04 Mar 2025
Nature Genetics

Volume: 57, P: 815-828
Does candesartan benefit patients with heart failure?

Christian Torp-Pedersen
Lars Køber
Comments & Opinion01 May 2006
Nature Clinical Practice Cardiovascular Medicine

Volume: 3, P: 250-251
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.

Sonia Shah
Albert Henry
R. Thomas Lumbers
ResearchOpen Access09 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Temporal changes in characteristics, incidence, and mortality in patients undergoing surgical intervention for mitral stenosis

Hans T. Due
Jeppe K. Petersen
Lauge Østergaard
ResearchOpen Access16 Oct 2024
Scientific Reports

Volume: 14, P: 1-10
Electronic nudges for sustained influenza vaccination uptake in older adults: the nationwide randomized NUDGE-FLU-2 trial

In the second season of a series of pragmatic trials involving all Danish citizens 65 years of age or older, electronic nudges increased influenza vaccination rates significantly with respect to usual care, with higher effect in individuals not vaccinated in the previous season.

Niklas Dyrby Johansen
Muthiah Vaduganathan
Tor Biering-Sørensen
Research30 Aug 2024
Nature Medicine

Volume: 30, P: 3142-3149
One third of Danish hypertrophic cardiomyopathy patients have mutations in MYH7 rod region

Lotte Hougs
Ole Havndrup
Paal Skytt Andersen
Research13 Oct 2004
European Journal of Human Genetics

Volume: 13, P: 161-165
De novo electrocardiographic abnormalities in persons living with HIV

Andreas D. Knudsen
Claus Graff
Susanne D. Nielsen
ResearchOpen Access21 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
Microbiome and metabolome features of the cardiometabolic disease spectrum

By studying individuals along a spectrum of cardiometabolic disease and adjusting for effects of lifestyle and medication, this investigation identifies alterations of the metabolome and microbiome from dysmetabolic conditions, such as obesity and type 2 diabetes, to ischemic heart disease.

Sebastien Fromentin
Sofia K. Forslund
Oluf Pedersen
ResearchOpen Access17 Feb 2022
Nature Medicine

Volume: 28, P: 303-314
Combinatorial, additive and dose-dependent drug–microbiome associations

An analysis of 2,173 individuals from the MetaCardis cohort quantifies the individual and combinatorial effects of a range of drugs on host health, metabolome and gut microbiome in cardiometabolic disease.

Sofia K. Forslund
Rima Chakaroun
Peer Bork
Research08 Dec 2021
Nature

Volume: 600, P: 500-505
Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

TMAO is known to be atherothrombotic. Here the authors show that i) kidney function is the main determinant of serum TMAO, ii) TMAO increases kidney scarring with TGF-β1 signalling and iii) anti-diabetic drugs with reno-protective properties such as GLP1R agonists reduce plasma TMAO.

Petros Andrikopoulos
Judith Aron-Wisnewsky
Marc-Emmanuel Dumas
ResearchOpen Access20 Sept 2023
Nature Communications

Volume: 14, P: 1-18
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

A cross-sectional analysis of participants in the MetaCardis Body Mass Index Spectrum cohort finds that the higher prevalence of gut microbiota dysbiosis in individuals with obesity is not observed in those who take statin drugs.

Sara Vieira-Silva
Gwen Falony
Jeroen Raes
Research06 May 2020
Nature

Volume: 581, P: 310-315
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.

Antonio Molinaro
Pierre Bel Lassen
Fredrik Bäckhed
ResearchOpen Access18 Nov 2020
Nature Communications

Volume: 11, P: 1-10
Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism

Genome-wide association analyses identify 93 risk loci for venous thromboembolism (VTE). A polygenic score derived from these results identifies individuals at increased VTE risk equivalent to monogenic forms of the disease.

Jonas Ghouse
Vinicius Tragante
Henning Bundgaard
Research19 Jan 2023
Nature Genetics

Volume: 55, P: 399-409
Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Antonio Molinaro
Pierre Bel Lassen
Fredrik Bäckhed
Amendments and CorrectionsOpen Access21 Dec 2020
Nature Communications

Volume: 11, P: 1
Erratum: One-third of Danish hypertrophic cardiomyopathy patients with MYH7 mutations have mutations in rod region

Lotte Hougs
Ole Havndrup
Paal Skytt Andersen
Amendments and Corrections25 Apr 2005
European Journal of Human Genetics

Volume: 13, P: 694
Subgrouping patients with ischemic heart disease by means of the Markov cluster algorithm

Haue, Holm et al. use unsupervised clustering to subgroup a large set of ischemic heart disease patients from their pre-existing diseases, covering the entire multimorbidity spectrum. They identify subgroups that have different risk profiles and are characterized by different patterns when looking at patient blood tests and genetic profiles.

Amalie D. Haue
Peter C. Holm
Søren Brunak
ResearchOpen Access26 Aug 2025
Communications Medicine

Volume: 5, P: 1-11
Dapagliflozin across the range of ejection fraction in patients with heart failure: a patient-level, pooled meta-analysis of DAPA-HF and DELIVER

A pre-specified meta-analysis of pooled, individual patient-level data from the DELIVER and DAPA-HF trials, testing dapagliflozin in patients with heart failure, demonstrates reductions in risk of cardiovascular-associated deaths and hospital admissions for heart failure, regardless of ejection fraction.

Pardeep S. Jhund
Toru Kondo
John J. V. McMurray
ResearchOpen Access27 Aug 2022
Nature Medicine

Volume: 28, P: 1956-1964
ECG and CT for the detection of left atrial enlargement in hypertensive individuals—a population-based study

Emma Julia Petronella Nilsson
Jørgen Tobias Kühl
Klaus Fuglsang Kofoed
Research28 Apr 2022
Hypertension Research

Volume: 45, P: 1382-1391
Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure

Peter R. Hansen
Karl Emil Nelveg-Kristensen
Christian Enevold
Research17 Jan 2019
The Pharmacogenomics Journal

Volume: 19, P: 428-437
The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy

Daniel Vega Møller
Paal Skytt Andersen
Lars Køber
Research18 Mar 2009
European Journal of Human Genetics

Volume: 17, P: 1241-1249

Search

Filter By:

Search

Quick links