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Showing 1–4 of 4 results
Advanced filters: Author: Laszlo Tirian Clear advanced filters

  • The ATPase UAP56 acts as an ATP-gated molecular switch that directs mRNA ribonucleoprotein complexes from TREX to nuclear-pore-complex-anchored TREX-2 complexes for mRNA export from the nucleus.

    • Ulrich Hohmann
    • Max Graf
    • Clemens Plaschka
    ResearchOpen Access
    Nature
    Volume: 649, P: 1042-1050

  • Transcription of Drosophila PIWI-interacting RNA (piRNA) clusters is enforced through RNA polymerase II pre-initiation complex formation within repressive heterochromatin, accomplished through the transcription factor IIA subunit paralogue Moonshiner.

    • Peter Refsing Andersen
    • Laszlo Tirian
    • Julius Brennecke
    Research
    Nature
    Volume: 549, P: 54-59

  • Cross-linking mass spectrometry faces challenges due to low reaction efficiencies and complex matrices in protein–protein interaction (PPI) studies. Here, the authors enhance an Azide-A-DSBSO-based in vivo crosslinking workflow with affinity enrichment and size exclusion chromatography, yielding over 5000 crosslinks from K562 cells and generating a comprehensive PPI network.

    • Philipp Bräuer
    • Laszlo Tirian
    • Manuel Matzinger
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-13