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Advanced filters: Author: Laura A. Blumensaadt Clear advanced filters

CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors

Epidermal progenitors are poised for differentiation, which allows for continual balance of self-renewal and differentiation. Here they show that the Super Elongation Complex regulates this process through direct regulation of a set of rapid response genes that involves a CDK9 activity switch.

Sarah M. Lloyd
Daniel B. Leon
Xiaomin Bao
ResearchOpen Access29 Jul 2022
Nature Communications

Volume: 13, P: 1-18
Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbers

Nucleoporins (NUPs) compose the nuclear pores. As skin epidermal cells switch from the progenitor state to differentiation, NUPs are downregulated without changing pore numbers. Downregulation of NUP93 is further connected to NF-kB activation.

Amy E. Neely
Yang Zhang
Xiaomin Bao
ResearchOpen Access18 Oct 2023
Communications Biology

Volume: 6, P: 1-16
NUP98 and RAE1 sustain progenitor function through HDAC-dependent chromatin targeting to escape from nucleolar localization

In epidermal progenitor cells, HDAC1 activity controls NUP98 and RAE1 localization in the regulation of epigenetic regulator genes, ensuring somatic tissue self-generation.

Amy E. Neely
Laura A. Blumensaadt
Xiaomin Bao
ResearchOpen Access23 Jun 2023
Communications Biology

Volume: 6, P: 1-15

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