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Showing 1–9 of 9 results
Advanced filters: Author: Laura A. Solt Clear advanced filters

  • Synthetic REV-ERB agonists can alter the circadian expression of core clock genes in the hypothalami of mice, which changes the expression of metabolic genes in liver, skeletal muscle and adipose tissue, and results in increased energy expenditure.

    • Laura A. Solt
    • Yongjun Wang
    • Thomas P. Burris
    Research
    Nature
    Volume: 485, P: 62-68

  • Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism. Here the authors present two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse agonist/corepressor-bound transcriptionally repressive conformation, where helix 12 is located within the orthosteric ligand-binding pocket instead, and discuss mechanistic implications.

    • Jinsai Shang
    • Sarah A. Mosure
    • Douglas J. Kojetin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Progesterone receptor membrane component 2 is required to transport haem from the mitochondria to the nucleus, where, in adipose tissue, it has roles in regulation of thermogenesis and glucose metabolism.

    • Andrea Galmozzi
    • Bernard P. Kok
    • Enrique Saez
    Research
    Nature
    Volume: 576, P: 138-142

  • Unlike RORα, which has been thought to be somewhat redundant, RORγt has been well characterized in its function and contribution to the development of Th17 cells. Here the authors show that RORα is important in Th17 differentiation and that RORα deletion or a small molecule inhibitor of RORα can reduce disease in EAE and colitis mouse models.

    • Ran Wang
    • Sean Campbell
    • Laura A. Solt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Synthetic compounds that alter circadian rhythms have been shown to modulate energy expenditure and systemic metabolism in rodents. Here, the authors study the psychological effects of such compounds, and find synthetic REV-ERB agonists increase wakefulness and reduce anxiety-like behaviour in mice.

    • Subhashis Banerjee
    • Yongjun Wang
    • Thomas P. Burris
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • Bart Staels and his colleagues show that the transcription factor Rev-erb-α is highly expressed in oxidative muscle and, via loss- and gain-of-function experiments, including pharmacological activation, that it plays a key partin regulating the oxidative capacity of the muscle and exercise endurance.

    • Estelle Woldt
    • Yasmine Sebti
    • Hélène Duez
    Research
    Nature Medicine
    Volume: 19, P: 1039-1046