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Assessing the causal association of glycine with risk of cardio-metabolic diseases

Epidemiological studies have associated circulating levels of the amino acid glycine with cardiometabolic outcomes. Here, in a genome-wide meta-analysis of 80,003 individuals, Wittemans et al. identify 22 novel genetic loci for glycine and find a causal relationship with coronary heart disease using MR.

Laura B. L. Wittemans
Luca A. Lotta
Claudia Langenberg
ResearchOpen Access05 Mar 2019
Nature Communications

Volume: 10, P: 1-13
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Genome-wide analyses identify variants associated with infertility and reproductive hormone levels but find limited polygenic overlap between reproductive hormone levels and infertility at the population level.

Samvida S. Venkatesh
Laura B. L. Wittemans
Cecilia M. Lindgren
ResearchOpen Access14 Apr 2025
Nature Genetics

Volume: 57, P: 1107-1118
Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records

Here, the authors identify six genetic variants associated with adult weight-change, by leveraging 24.5 million weight records from the UK, USA, and Estonia. These variants influence weight change independently of baseline weight.

Samvida S. Venkatesh
Habib Ganjgahi
George Nicholson
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-19
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

Our understanding of the genetic contribution to human adiposity is incomplete, as few studies measure adiposity directly. Here, the authors impute whole-body imaging adiposity phenotypes in large biobanks, enhancing their power to discover genes driving human adiposity, and further investigate one such gene using a mouse model.

Katherine A. Kentistou
Jian’an Luan
Nicholas M. Morton
ResearchOpen Access19 Jan 2023
Nature Communications

Volume: 14, P: 1-12
A cross-platform approach identifies genetic regulators of human metabolism and health

A large-scale genome-wide meta-analysis conducted across different platforms identifies genetic loci regulating levels of circulating metabolites.

Luca A. Lotta
Maik Pietzner
Claudia Langenberg
Research07 Jan 2021
Nature Genetics

Volume: 53, P: 54-64
Rare and common genetic determinants of metabolic individuality and their effects on human health

Analyses of the genetic architecture of the human plasma metabolome in two large population-based cohorts identify associations between genetically determined metabolite levels and health.

Praveen Surendran
Isobel D. Stewart
Claudia Langenberg
ResearchOpen Access10 Nov 2022
Nature Medicine

Volume: 28, P: 2321-2332
Using human genetics to understand the disease impacts of testosterone in men and women

Genetic analysis of data from over 400,000 participants in the UK Biobank Study shows that circulating testosterone levels have sex-specific implications for cardiometabolic diseases and cancer outcomes.

Katherine S Ruth
Felix R Day
John R. B. Perry
Research10 Feb 2020
Nature Medicine

Volume: 26, P: 252-258

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Assessing the causal association of glycine with risk of cardio-metabolic diseases

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records

Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

A cross-platform approach identifies genetic regulators of human metabolism and health

Rare and common genetic determinants of metabolic individuality and their effects on human health

Using human genetics to understand the disease impacts of testosterone in men and women

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Assessing the causal association of glycine with risk of cardio-metabolic diseases

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records

Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

A cross-platform approach identifies genetic regulators of human metabolism and health

Rare and common genetic determinants of metabolic individuality and their effects on human health

Using human genetics to understand the disease impacts of testosterone in men and women

Search

Quick links