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Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model

USP30 has been proposed to regulate mitophagy, a relevant Parkinson’s disease mechanism. Here, the authors show that Usp30 knockout mice and USP30 inhibitors like MTX115325 demonstrate neuroprotective responses in an alpha-synuclein mouse model of Parkinson’s disease.

Tracy-Shi Zhang Fang
Yu Sun
David K. Simon
ResearchOpen Access13 Nov 2023
Nature Communications

Volume: 14, P: 1-16

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