Nature Search

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
ResearchOpen Access06 Dec 2021
Nature Genetics

Volume: 53, P: 1636-1648
Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity

Fresia Pareja
Edaise M. da Silva
Edi Brogi
Research02 Jan 2020
Modern Pathology

Volume: 33, P: 1056-1064
Transancestral mapping and genetic load in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.

Carl D. Langefeld
Hannah C. Ainsworth
Timothy J. Vyse
ResearchOpen Access17 Jul 2017
Nature Communications

Volume: 8, P: 1-18
Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program

Johanna T. W. Wigman
Ann Ee Ching
John Torous
ResearchOpen Access03 Jun 2025
Schizophrenia

Volume: 11, P: 1-10
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

Russell L. McLaughlin
Dick Schijven
Michael C. O’Donovan
ResearchOpen Access21 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
Amendments and CorrectionsOpen Access31 Jan 2022
Nature Genetics

Volume: 54, P: 361
In Vivo Flow Mapping in Complex Vessel Networks by Single Image Correlation

Laura Sironi
Margaux Bouzin
Giuseppe Chirico
ResearchOpen Access05 Dec 2014
Scientific Reports

Volume: 4, P: 1-8
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer
Garrett Hellenthal
Alastair Compston
Research10 Aug 2011
Nature

Volume: 476, P: 214-219
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis

David R Booth
Robert N Heard
Jonathan Haines
Correspondence01 Jun 2010
Nature Genetics

Volume: 42, P: 469-470
Use of smartphone-based remote assessments of multiple sclerosis in Floodlight Open, a global, prospective, open-access study

Jiwon Oh
Luca Capezzuto
Michael Lindemann
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-16
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

The International Multiple Sclerosis Genetics Consortium reports the discovery of 48 new susceptibility variants for multiple sclerosis through targeted follow-up of immune-related loci. They also report fine mapping of association signals at established susceptibility loci and provide insights into the immune system processes underlying this disease.

Ashley H Beecham
Nikolaos A Patsopoulos
Jacob L McCauley
Research29 Sept 2013
Nature Genetics

Volume: 45, P: 1353-1360
Author Correction: μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure

F. Radaelli
L. D’Alfonso
L. Sironi
Amendments and CorrectionsOpen Access17 Apr 2018
Scientific Reports

Volume: 8, P: 1
μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure

F. Radaelli
L. D’Alfonso
L. Sironi
ResearchOpen Access12 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Jan Hudeček
Leonie Voorwerk
Zsuzsanna Bago-Horvath
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-8

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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity

Transancestral mapping and genetic load in systemic lupus erythematosus

Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

In Vivo Flow Mapping in Complex Vessel Networks by Single Image Correlation

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis

Use of smartphone-based remote assessments of multiple sclerosis in Floodlight Open, a global, prospective, open-access study

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Author Correction: μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure

μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

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