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Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

The protein Cereblon, part of an ubiquitin E3 ligase complex, is the target for anticancer thalidomide analogs. The crystal structure of human Cereblon-DDB1 with bound lenalidomide reveals how the drug affects E3 substrate recruitment.

Philip P Chamberlain
Antonia Lopez-Girona
Brian E Cathers
Research10 Aug 2014
Nature Structural & Molecular Biology

Volume: 21, P: 803-809
The role of dopamine in dynamic effort-reward integration

Jochen Michely
Shivakumar Viswanathan
Christian Grefkes
ResearchOpen Access08 Apr 2020
Neuropsychopharmacology

Volume: 45, P: 1448-1453

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Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

The role of dopamine in dynamic effort-reward integration

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