Electrostatic force microscopy with sub-piconewton resolution can now be used for the label-free identification of single dielectric nanoparticles of similar morphology but distinct low-polarizable materials. The technique can also distinguish between empty and DNA-containing virus capsids, and should be extensible to the characterization of surface and subsurface dielectric properties of nanoscale dielectrics and biological macromolecules in general.
- Laura Fumagalli
- Daniel Esteban-Ferrer
- Gabriel Gomila