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Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial

Results from the randomized, noncomparative, phase 2 MATISSE trial show that ultra-short neoadjuvant therapy with ipilimumab and nivolumab can prevent surgery and radiotherapy in patients with resectable cutaneous squamous cell carcinoma, with an early decrease in total lesion glycolysis by [¹⁸F]FDG-PET/CT associated with response.

Sabine E. Breukers
Joleen J. H. Traets
Charlotte L. Zuur
ResearchOpen Access08 Oct 2025
Nature Medicine

Volume: 31, P: 4055-4064
Myocardial infarction augments sleep to limit cardiac inflammation and damage

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic signalling and assists healing.

Pacific Huynh
Jan D. Hoffmann
Cameron S. McAlpine
Research30 Oct 2024
Nature

Volume: 635, P: 168-177
Signatures of V_H1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins

The burden of chronic hepatitis C virus infection is exacerbated by the lack of an effective vaccine. In this work, authors use a recombinant permuted (E2E1) HCV glycoprotein design to analyze the binding of different VH1-69-derived AR3-directed broadly neutralizing antibodies to the viral envelope glycoprotein.

Joan Capella-Pujol
Marlon de Gast
Kwinten Sliepen
ResearchOpen Access07 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate

E1E2 spike on the hepatitis C virion is an important target for vaccine design. Here, the authors permute the subunits to generate E2E1 immunogens and show that mosaic nanoparticles displaying different E2E1 antigens elicit cross-neutralizing antibodies in rabbits.

Kwinten Sliepen
Laura Radić
Rogier W. Sanders
ResearchOpen Access25 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Diagnosis and management of Cornelia de Lange syndrome: first international consensus statement

Cornelia de Lange syndrome is a genetic disorder affecting multiple organ systems that exhibits great phenotypic heterogeneity. This Consensus Statement summarizes recommendations for the diagnosis and management of patients with Cornelia de Lange syndrome.

Antonie D. Kline
Joanna F. Moss
Raoul C. Hennekam
ReviewsOpen Access11 Jul 2018
Nature Reviews Genetics

Volume: 19, P: 649-666
Effects of lifestyle factors on leukocytes in cardiovascular health and disease

In this Review, Swirski and co-workers discuss how lifestyle factors modulate haematopoiesis and leukocyte migration in the context of cardiovascular homeostasis and disease, with particular focus on the role of the nervous system as the key executor connecting environmental influences to leukocyte behaviour.

Henrike Janssen
Laura L. Koekkoek
Filip K. Swirski
Reviews26 Sept 2023
Nature Reviews Cardiology

Volume: 21, P: 157-169

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Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial

Myocardial infarction augments sleep to limit cardiac inflammation and damage

Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins

Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate

Diagnosis and management of Cornelia de Lange syndrome: first international consensus statement

Effects of lifestyle factors on leukocytes in cardiovascular health and disease

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Signatures of V_H1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins