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Showing 1–6 of 6 results
Advanced filters: Author: Laura Leonhardt Clear advanced filters

  • Silencing of endogenous retroviral elements (ERVs) is mediated by KAP1. Here, the authors describe the molecular mechanism by which KAP1 induces structural reorganization and multimerization of HP1α and maintains inaccessible chromatin at ERVs in mouse embryonic stem cells.

    • Nitika Gaurav
    • Ryan O’Hara
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. Here the authors find that CTCF positions cohesin through its N-terminus but does not control its overall binding dynamics on chromatin, and show how the orientation of CTCF binding sites translates into genome folding patterns.

    • Elphège P. Nora
    • Laura Caccianini
    • Benoit G. Bruneau
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Genome sequencing alone fails to provide a genetic diagnosis for many Mendelian disorder patients. Here, the authors utilize RNA sequencing to complement genotyping of patients with a rare mitochondrial disease by detecting aberrant RNA expression, splicing and allele-specific expression.

    • Laura S. Kremer
    • Daniel M. Bader
    • Holger Prokisch
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Effectively targeting deregulated KRAS signaling remains an unmet clinical need, as current approaches commonly lead to the development of chemoresistance in clinical settings. ADAM9-mediated lysosomal KRAS degradation is now shown to counteract PDAC chemoresistance independently of mutational status.

    • Laura Leonhardt
    • Matthias Hebrok
    News & Views
    Nature Cancer
    Volume: 5, P: 375-377

  • Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of the cell cycle regulator c-Myc.

    • Sapna Puri
    • Nilotpal Roy
    • Matthias Hebrok
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12