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Showing 1–2 of 2 results
Advanced filters: Author: Laura Lorenzo-Sanz Clear advanced filters

  • Immune surveillance is critical to prevent the development and progression of cutaneous squamous cell carcinoma (cSCC). Here, the authors show that epithelial-mesenchymal plasticity in cancer cells is associated with changes in their immune checkpoint ligand profile during mouse cSCC progression, which dictates differential responses to immune checkpoint blockade.

    • Laura Lorenzo-Sanz
    • Marta Lopez-Cerda
    • Purificación Muñoz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Small proteins encoded by previously assumed non-coding RNAs can have cell regulatory functions. Here the authors report that TINCR lncRNA encodes pTINCR, a ubiquitin-like protein (UBL) that promotes epithelial differentiation through the SUMOylation and activation of CDC42, and it has tumour suppressor activity in epithelial cancers.

    • Olga Boix
    • Marion Martinez
    • María Abad
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-22