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Showing 1–5 of 5 results
Advanced filters: Author: Laura Novellasdemunt Clear advanced filters

  • A poor prognosis gene programme in patients with colorectal cancer is expressed by a unique tumour cell population that we name high-relapse cells (HRCs), and ablation of cells expressing the HRC marker EMP1 or neoadjuvant immunotherapy prevented metastatic recurrence in mice.

    • Adrià Cañellas-Socias
    • Carme Cortina
    • Eduard Batlle
    Research
    Nature
    Volume: 611, P: 603-613

  • Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion diet in mouse xenograft models.

    • Mylène Tajan
    • Marc Hennequart
    • Karen H. Vousden
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Metabolic compensation equips tumours with the plasticity to circumvent individual nutrient pathway perturbation. Méndez-Lucas et al. demonstrate the power of synergistic targeting of multiple metabolic pathways to stymie liver tumourigenesis.

    • Andrés Méndez-Lucas
    • Wei Lin
    • Mariia Yuneva
    Research
    Nature Metabolism
    Volume: 2, P: 335-350

  • In a first step toward developing autologous tissue grafts for the treatment of children with intestinal failure, patient-derived jejunal organoids seeded on scaffolds of decellularized human intestinal matrix formed grafts that had jejunal properties and formed luminal structures when transplanted into mice.

    • Laween Meran
    • Isobel Massie
    • Vivian S. W. Li
    Research
    Nature Medicine
    Volume: 26, P: 1593-1601