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Showing 1–6 of 6 results
Advanced filters: Author: Laura Ordovas Clear advanced filters

  • Sekar Kathiresan et al. report genome-wide association studies for polygenic dyslipidemia. From a meta-analysis of seven genome-wide association studies and follow-up in five replication studies, they identify 11 new genetic associations for LDL cholesterol, HDL cholesterol and triglycerides.

    • Sekar Kathiresan
    • Cristen J Willer
    • L Adrienne Cupples
    Research
    Nature Genetics
    Volume: 41, P: 56-65

  • Amyotrophic lateral sclerosis (ALS) leads to selective loss of motor neurons. Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.

    • Wenting Guo
    • Maximilian Naujock
    • Ludo Van Den Bosch
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • A multimodal analysis of patients with 22 different immune-mediated monogenic diseases versus matched healthy controls leads to the development of the immune health metric, which could be implemented broadly to predict responses to aging, vaccination and other immune perturbations.

    • Rachel Sparks
    • Nicholas Rachmaninoff
    • John S. Tsang
    Research
    Nature Medicine
    Volume: 30, P: 2461-2472

  • Hepatocytes grown in a dish are immature and do not metabolize compounds as a real liver would. Here, the authors supply stem cell-derived hepatocytes with amino acids at a higher concentration than nutritionally necessary, changing the metabolism of these cells, making them more mature and useful for drug screening and toxicity studies.

    • Ruben Boon
    • Manoj Kumar
    • Catherine M. Verfaillie
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16