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Showing 1–2 of 2 results
Advanced filters: Author: Laura Pascual-Reguant Clear advanced filters

  • Metabolism plays an important role in response to DNA damage, however the underlying mechanisms are less clear. Here, the authors identify a non-canonical role of IMPDH2 wherein it is recruited to the chromatin following DNA damage and mediates PARP1-dependent DNA damage repair via the regulation of nuclear NAD+ levels.

    • Lorena Espinar
    • Marta Garcia-Cao
    • Sara Sdelci
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Lamina-associated domains (LADs) contact lamins in the nuclear lamina, and lamin B1 was thought to bind heterochromatic regions at the nuclear envelope. Here, the authors show lamin B1 associates with actively expressed euchromatin regions, creating dynamic euchromatin lamina-associated domains (eLADs) during epithelial-to-mesenchymal transition.

    • Laura Pascual-Reguant
    • Enrique Blanco
    • Sandra Peiró
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12