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Showing 1–6 of 6 results

Advanced filters: Author: Laura Sebastian Monasor Clear advanced filters

Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Samira Parhizkar
Thomas Arzberger
Christian Haass
Amendments and Corrections14 Aug 2024
Nature Neuroscience

Volume: 27, P: 1858-1859
Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Niemann-Pick type C disease is a rare childhood neurodegenerative disorder predominantly caused by mutations in NPC1, resulting in abnormal late endosomal and lysosomal defects. Here the authors show that NPC1 disruption largely impairs microglial function.

Alessio Colombo
Lina Dinkel
Sabina Tahirovic
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-20
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Loss of Trem2 function increases early amyloidogenesis by preventing microglial activation and clustering around amyloid seeds. As a consequence of reduced microglial ApoE production in the absence of Trem2 function, amyloid plaques contain less ApoE.

Samira Parhizkar
Thomas Arzberger
Christian Haass
Research07 Jan 2019
Nature Neuroscience

Volume: 22, P: 191-204
Microglia contribute to the propagation of Aβ into unaffected brain tissue

This study shows that Aβ from transgenic host tissue is able to enter and deposit within wild-type grafts via microglia, thus identifying microglia as carriers of Aβ deposition into previously unaffected brain tissue.

Paolo d’Errico
Stephanie Ziegler-Waldkirch
Melanie Meyer-Luehmann
ResearchOpen Access22 Nov 2021
Nature Neuroscience

Volume: 25, P: 20-25
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease

Barbara Bettegazzi
Laura Sebastian Monasor
Daniele Zacchetti
ResearchOpen Access04 Aug 2021
Cell Death & Disease

Volume: 12, P: 1-14
Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain

Polyxeni Nikolakopoulou
Antonios Chatzigeorgiou
Andreas Androutsellis-Theotokis
ResearchOpen Access27 Jul 2018
Scientific Reports

Volume: 8, P: 1-15