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Showing 1–5 of 5 results
Advanced filters: Author: Laura Segatori Clear advanced filters

  • Engineering cell factories that support the production of large quantities of protein therapeutics remains a significant biomanufacturing challenge. Here the authors engineered cells to sense an early marker of the Unfolded Protein Response (UPR) and, in response, modulate specific UPR signaling pathways mediating stress attenuation and/or apoptosis.

    • Daniela Barrios
    • Bhagyashree Bachhav
    • Laura Segatori
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Engineering of a synthetic circuit that couples transcriptional and protein turnover regulation to a fluorescent protein readout enables sensitive monitoring and amplification of gene expression signals from the unfolded protein response pathway.

    • Carlos A. Origel Marmolejo
    • Bhagyashree Bachhav
    • Laura Segatori
    Research
    Nature Chemical Biology
    Volume: 16, P: 520-528

  • Proteasome activity can be monitored using a fluorescent substrate; however, screening for proteasome activators using this technique is challenging as signal loss is intrinsically more difficult to detect. Zhao et al.design a genetic inverter circuit that reports increased proteasome activity as signal gain.

    • Wenting Zhao
    • Matthew Bonem
    • Laura Segatori
    Research
    Nature Communications
    Volume: 5, P: 1-12

  • The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose acts by inhibiting Akt, which normally suppresses TFEB via an mTORC1-independent mechanism.

    • Michela Palmieri
    • Rituraj Pal
    • Marco Sardiello
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

  • di Ronza et al. identify CLN8 as a cargo receptor for lysosomal enzymes required for their endoplasmic-reticulum-to-Golgi transport, linking Batten disease caused by CLN8 mutations to defects in organelle biogenesis.

    • Alberto di Ronza
    • Lakshya Bajaj
    • Marco Sardiello
    Research
    Nature Cell Biology
    Volume: 20, P: 1370-1377