Conditions such as diabetes, metabolic syndrome and chronic inflammation can induce extensive post-translational modifications in cartilage structural proteins, with consequences for the molecular structure and, ultimately, the function of cartilage. This article reviews the biochemical changes to articular cartilage matrix proteins driven by metabolic and oxidative stress as well as their relationship with cartilage degeneration.
- John A. Hardin
- Neil Cobelli
- Laura Santambrogio
